USD 2.80 Billion
Bone Graft Substitutes Market Size, Share, Growth Analysis, By Material Type (Allograft, Synthetic), By Application (Craniomaxillofacial, Joint Reconstruction), By End User, By Region - Industry Forecast 2025-2032
Report ID:
SQMIG35A2257 |
Region:
Global |
Published Date: November, 2024
Pages:
219
|Tables:
64
|Figures:
75
Bone Graft Substitutes Market Insights
Bone Graft Substitutes Market size was valued at USD 1.28 Billion in 2023 and is poised to grow from USD 1.37 Billion in 2024 to USD 2.29 Billion by 2032, growing at a CAGR of 6.70% during the forecast period (2025-2032).
The global market for bone graft substitutes is expected to experience substantial growth during the forecast period due to increasing demand for synthetic substitutes and the approval of new products by regulatory authorities. For instance, in July 2020, Baxter obtained clearance from the U.S. FDA for its Altapore Shape Bioactive Bone Graft, expanding its bone graft substitute lineup. The adoption of bone grafts and substitutes has been driven by their advantages, such as biocompatibility, safety, and ability to promote bone healing. The demand for biocompatible bone grafts is also on the rise as they help reduce adverse reactions. Synthetic grafts containing Hydroxyapatite (HAp) and Tricalcium Phosphate (TCP) have gained popularity due to their superior biocompatibility.
The market expansion is further supported by a favorable regulatory framework and efforts by market participants to develop new products with enhanced bioactivity, biocompatibility, and mechanical properties. For example, Graftys received certification for its bone void fillers and delivery systems, while Molecular Matrix launched the Osteo-P Synthetic Bone Graft Substitute with advanced technology for bone regeneration and repair. Additionally, the increasing adoption of minimally invasive procedures is driving the demand for bone grafts and substitutes. Surgeons prefer these procedures over traditional approaches due to their benefits, including shorter recovery time, reduced hospital stays, and smaller incisions. The number of minimally invasive orthopedic procedures performed in the United States has been steadily increasing, according to data from the American Academy of Orthopedic Surgeons (AAOS). Procedures such as arthroscopy, spine surgeries, fracture repair, and joint replacement contribute to the market's significant growth pace.
Market snapshot - 2024-2031
Global Market Size
Largest Segment
Autografts
Fastest Growth
Autografts
Growth Rate
6.30% CAGR
Global Bone Graft Substitutes Market ($ Bn)
Country Share for North America Region (%)
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Bone Graft Substitutes Market Segmental Analysis
Global Bone Grafts and Substitutes Market is segmented by Material Type, Application, End User and Region. Based on Material Type, the market is segmented into Allograft, Synthetic. Based on Application, the market is segmented into Craniomaxillofacial, Dental, Foot & Ankle, Joint Reconstruction, Long Bone, and Spinal Fusion. Based on End User, the market is segmented into Hospitals, Specialty clinics, and Others. Based on region, the market is segmented into North America, Europe, Asia Pacific, Latin America and Middle East & and Africa.
Analysis by Type
In terms of material type, the market is divided into allografts, synthetics, composites, polymers, and bone morphogenic proteins (BMP). Allografts accounted for the largest revenue share in the material type segment in 2023 and are expected to see significant growth during the forecast period. Allograft adoption is increasing due to properties like osteoconductivity and immediate structural support. Positive patient outcomes and recent allograft launches also contribute to this segment’s expansion. Allografts have the advantage of not requiring additional surgery for bone harvesting, leading to faster wound healing, shorter surgery times, and higher success rates. For example, a study published by NCBI in February 2022 reported allograft bone fusion success rates between 87% and 94.3%.
The synthetic segment is projected to experience the fastest growth. This growth is attributed to lower disease transmission risk, better biocompatibility, and greater patient acceptance compared to allografts. Within the synthetic segment, subcategories include ceramics, composites, polymers, and BMP. Rising orthopedic disorder prevalence and increased demand for synthetic products in developed countries are driving factors for this segment.
Analysis by Application
The global bone grafts and substitutes market is segmented by application into dental, craniomaxillofacial, joint reconstruction, foot & ankle, long bone, and spinal fusion. The spinal fusion segment held the largest market share in 2023, driven by the increasing adoption of bone graft materials for spondylosyndesis and the rising geriatric population prone to orthopedic ailments. This high number of elderly individuals is fueling demand for orthopedic solutions.
The dental segment is anticipated to witness the fastest CAGR growth over the forecast period due to the rising adoption of grafts for dental procedures. Bone grafts are used as scaffolds and fillers to facilitate bone formation and promote healing. The increasing acceptance of dental implant surgical procedures, along with advanced techniques such as bone grafts and bone regeneration, are projected to boost market growth. Moreover, the rising success rates of dental implants are also resulting in high demand for bone grafts and substitutes.
Global Bone Graft Substitutes Market By Application
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Bone Graft Substitutes Market Regional Insights
North America dominated the global bone graft substitutes market. The region's dominance can be attributed to several factors, including advanced healthcare infrastructure, high healthcare expenditure, favorable reimbursement policies, and extensive research and development activities. The United States, in particular, plays a major role in driving market growth in North America, with a well-established healthcare system and a large patient population. Furthermore, the presence of key market players and their focus on developing innovative bone graft substitutes contribute to the region's dominance.
On the other hand, the Asia-Pacific region is experiencing rapid growth and is considered the fastest-growing market for bone graft substitutes. APAC market growth is driven by factors such as increasing healthcare expenditure, rising awareness about the benefits of bone graft substitutes, improving healthcare infrastructure, and a growing aging population. Countries like China, Japan, and India are witnessing significant market growth due to the increasing prevalence of orthopaedic conditions, rising disposable incomes, and a shift towards advanced healthcare technologies.
Global Bone Graft Substitutes Market By Region
- Largest
- Fastest
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Bone Graft Substitutes Market Dynamics
Drivers
Increasing prevalence of orthopaedic conditions and musculoskeletal disorders
- One significant driver in the global bone graft substitutes market is the increasing prevalence of orthopaedic conditions and musculoskeletal disorders. Factors such as sedentary lifestyles, aging population, sports-related injuries, and accidents contribute to the rising incidence of fractures and bone-related ailments. As a result, there is a growing demand for effective bone graft substitutes to aid in bone regeneration and healing. This driver highlights the need for innovative solutions in the market to cater to the increasing patient pool and address the challenges associated with orthopaedic conditions.
Demand For Minimally Invasive Procedures
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The growing demand for minimally invasive orthopedic procedures is a key driving factor for the bone grafts and substitutes market. Advancements in medical technology are continuously improving the efficacy and safety of minimally invasive surgeries, leading surgeons to increasingly rely on innovative techniques and materials for bone grafting. These minimally invasive approaches offer benefits like reduced patient trauma, shorter recovery times, and better outcomes. As a result, there is a rising preference among patients and healthcare providers for minimally invasive bone grafting procedures that utilize advanced bone graft substitute materials. The ongoing research and development of more effective and accessible bone repair solutions is further fueling the adoption of minimally invasive techniques that leverage these innovative bone grafting substitutes. This growing preference for minimally invasive orthopedic procedures is a major driver propelling the expansion of the global bone grafts and substitutes market.
Restraints
High cost associated with these products
- One major restraint in the global bone graft substitutes market is the high cost associated with these products. The advanced technologies and materials used in bone graft substitutes contribute to their expensive nature. This cost factor can limit the adoption of bone graft substitutes, especially in emerging economies and regions with limited healthcare budgets. Additionally, the lack of reimbursement coverage for these products in some healthcare systems further hinders their accessibility. The high cost of bone graft substitutes poses a challenge for patients, healthcare providers, and healthcare systems seeking affordable treatment options for bone-related conditions.
Regulatory Challenges
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Safety and efficacy concerns, as well as regulatory hurdles for new products, are restraining factors for the bone grafting substitute market. Validating the safety and efficacy of bone graft materials necessitates high-quality clinical studies, which can be challenging and time-consuming. There are also potential risks and complications associated with bone grafting procedures that need to be carefully considered. From a regulatory perspective, obtaining approvals for new bone graft substitute products can be a lengthy process with stringent requirements around demonstrating safety and effectiveness. This creates barriers for companies looking to bring innovative materials and technologies to market. The need to comply with evolving regulations in different countries also adds complexity. These safety, efficacy and regulatory hurdles are limiting the pace at which new bone grafting substitutes can be developed and adopted, restraining the overall growth of this market segment.
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Bone Graft Substitutes Market Competitive Landscape
Global bone graft substitutes market is characterized by a diverse range of market players, including both established companies and emerging players. These players are focused on research and development activities to introduce innovative bone graft substitutes that offer enhanced biocompatibility, safety, and efficacy. Additionally, strategic collaborations, partnerships, and mergers and acquisitions are common strategies adopted by companies to strengthen their market position. The competitive landscape is driven by a continuous quest for technological advancements and the development of cost-effective solutions that cater to the evolving needs of healthcare providers and patients.
Bone Graft Substitutes Market Top Player’s Company Profiles
- AlloSource (US)
- Smith + Nephew (UK)
- Medtronic (Ireland)
- Orthofix US LLC (US)
- Pietro Fiorentini S.p.A. (Italy)
- TBF (France)
- OST Laboratories (France)
- Geistlich Pharma AG (Switzerland)
- Stryker (US)
- Biobank (UK)
- Aichi Tokei Denki Co., Ltd. (Japan)
- Chongqing Shancheng Gas Equipment Co., Ltd. (China)
- Flonidan A/S (Denmark)
- EMH metering GmbH & Co. KG (Germany)
- Badger Meter, Inc. (US)
- Wasion Group Holdings Limited (Star Treasure Investments Holdings Limited) (China)
- Holley Technology Ltd. (Holley Group) (China)
- Qianwei Kromschroder Meters Co., Ltd. (China)
- Secure Meters Limited (India)
- IMAC Systems, Inc. (US)
- Metrix Meter (Poland)
Bone Graft Substitutes Market Recent Developments
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In May 2024, Irvine-based Biogennix, LLC, an osteobiologics company, has announced the receipt of U.S. Food and Drug Administration (FDA) 510(k) clearance for expanded indications of its Agilon Moldable and Morpheus Moldable bone grafting products.
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In Jan 2024, Cerapedics Inc., an orthopedics company at the forefront of bone repair innovation, has announced the submission of the final module in their Pre-Market Approval (PMA) application to the U.S. Food and Drug Administration (FDA) for the P-15 Peptide Enhanced Bone Graft. This submission marks a significant milestone for Cerapedics, as it could lead to the approval of their second Class III drug/device combination product designed for lumbar spine fusion with a TLIF indication.
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In October 2023, Orthofix Medical Inc. (NASDAQ:OFIX), a global leader in spine and orthopedics, has announced the 510k clearance and full commercial launch of OsteoCove™, a cutting-edge bioactive synthetic graft.
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In May 2023, Zimmer Biomet Holdings, Inc. announced the launch of its VIVIX 3D Printed Bone Matrix, a breakthrough bone graft substitute with a porous structure designed to mimic the natural bone environment.
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In April 2023, Stryker Corporation acquired NuVasive, Inc., a leading provider of spine surgery solutions, expanding its product portfolio in the bone graft substitutes market and strengthening its presence in the spine care segment.
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In February 2023, Osseus Fusion Systems received FDA clearance for its ARIES-TS spinal implant system, designed for use with autograft or bone graft substitutes in posterior lumbar interbody fusion (PLIF) surgeries.
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In December 2022, Kuros Biosciences announced a collaboration with Johnson & Johnson Medical Devices Companies to co-develop innovative orthobiologic solutions for bone graft substitutes and regenerative medicine.
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In September 2022, SeaSpine Holdings Corporation launched the Mariner MIS Posterior Fixation System, an innovative platform that combines pedicle screw fixation and bone grafting options for minimally invasive spinal fusion procedures.
Bone Graft Substitutes Key Market Trends
- One key market trend in the global bone graft substitutes market is the growing focus on the development of bioactive and tissue-engineered graft substitutes. These advanced graft substitutes offer improved biocompatibility and promote faster bone healing. The integration of technologies such as 3D printing and nanotechnology has enabled the creation of customized graft substitutes with enhanced structural and mechanical properties. This trend highlights the industry's commitment to innovation and the pursuit of solutions that can mimic natural bone tissue, leading to improved patient outcomes and reduced complications in bone graft procedures.
Bone Graft Substitutes Market SkyQuest Analysis
SkyQuest’s ABIRAW (Advanced Business Intelligence, Research & Analysis Wing) is our Business Information Services team that Collects, Collates, Co-relates, and Analyses the Data collected by means of Primary Exploratory Research backed by robust Secondary Desk research.
According to our global bone graft substitutes market analysis, the increasing demand for synthetic substitutes, coupled with rising product approvals by regulatory authorities, is driving market expansion. Advantages such as biocompatibility, safety, and osteoconductivity have further propelled the adoption of bone grafts and substitutes. North America dominated the market, benefiting from advanced healthcare infrastructure and the presence of key players. Meanwhile, the Asia-Pacific region is the fastest-growing market, driven by increasing healthcare expenditure and a growing aging population. However, the high cost of bone graft substitutes remains a restraint. The market trend focuses on developing bioactive and tissue-engineered graft substitutes to enhance biocompatibility and accelerate bone healing.
| Report Metric | Details |
|---|---|
| Market size value in 2022 | USD 1.2 billion |
| Market size value in 2031 | USD 2.15 billion |
| Growth Rate | 6.70% |
| Base year | 2023 |
| Forecast period | 2024-2031 |
| Forecast Unit (Value) | USD Billion |
| Segments covered |
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| Regions covered | North America (US, Canada), Europe (Germany, France, United Kingdom, Italy, Spain, Rest of Europe), Asia Pacific (China, India, Japan, Rest of Asia-Pacific), Latin America (Brazil, Rest of Latin America), Middle East & Africa (South Africa, GCC Countries, Rest of MEA) |
| Companies covered |
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| Customization scope | Free report customization with purchase. Customization includes:-
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Table Of Content
Executive Summary
Market overview
- Exhibit: Executive Summary – Chart on Market Overview
- Exhibit: Executive Summary – Data Table on Market Overview
- Exhibit: Executive Summary – Chart on Bone Graft Substitutes Market Characteristics
- Exhibit: Executive Summary – Chart on Market by Geography
- Exhibit: Executive Summary – Chart on Market Segmentation
- Exhibit: Executive Summary – Chart on Incremental Growth
- Exhibit: Executive Summary – Data Table on Incremental Growth
- Exhibit: Executive Summary – Chart on Vendor Market Positioning
Parent Market Analysis
Market overview
Market size
- Market Dynamics
- Exhibit: Impact analysis of DROC, 2021
- Drivers
- Opportunities
- Restraints
- Challenges
- Exhibit: Impact analysis of DROC, 2021
- SWOT Analysis
KEY MARKET INSIGHTS
- Technology Analysis
- (Exhibit: Data Table: Name of technology and details)
- Pricing Analysis
- (Exhibit: Data Table: Name of technology and pricing details)
- Supply Chain Analysis
- (Exhibit: Detailed Supply Chain Presentation)
- Value Chain Analysis
- (Exhibit: Detailed Value Chain Presentation)
- Ecosystem Of the Market
- Exhibit: Parent Market Ecosystem Market Analysis
- Exhibit: Market Characteristics of Parent Market
- IP Analysis
- (Exhibit: Data Table: Name of product/technology, patents filed, inventor/company name, acquiring firm)
- Trade Analysis
- (Exhibit: Data Table: Import and Export data details)
- Startup Analysis
- (Exhibit: Data Table: Emerging startups details)
- Raw Material Analysis
- (Exhibit: Data Table: Mapping of key raw materials)
- Innovation Matrix
- (Exhibit: Positioning Matrix: Mapping of new and existing technologies)
- Pipeline product Analysis
- (Exhibit: Data Table: Name of companies and pipeline products, regional mapping)
- Macroeconomic Indicators
COVID IMPACT
- Introduction
- Impact On Economy—scenario Assessment
- Exhibit: Data on GDP - Year-over-year growth 2016-2022 (%)
- Revised Market Size
- Exhibit: Data Table on Bone Graft Substitutes Market size and forecast 2021-2027 ($ million)
- Impact Of COVID On Key Segments
- Exhibit: Data Table on Segment Market size and forecast 2021-2027 ($ million)
- COVID Strategies By Company
- Exhibit: Analysis on key strategies adopted by companies
MARKET DYNAMICS & OUTLOOK
- Market Dynamics
- Exhibit: Impact analysis of DROC, 2021
- Drivers
- Opportunities
- Restraints
- Challenges
- Exhibit: Impact analysis of DROC, 2021
- Regulatory Landscape
- Exhibit: Data Table on regulation from different region
- SWOT Analysis
- Porters Analysis
- Competitive rivalry
- Exhibit: Competitive rivalry Impact of key factors, 2021
- Threat of substitute products
- Exhibit: Threat of Substitute Products Impact of key factors, 2021
- Bargaining power of buyers
- Exhibit: buyers bargaining power Impact of key factors, 2021
- Threat of new entrants
- Exhibit: Threat of new entrants Impact of key factors, 2021
- Bargaining power of suppliers
- Exhibit: Threat of suppliers bargaining power Impact of key factors, 2021
- Competitive rivalry
- Skyquest special insights on future disruptions
- Political Impact
- Economic impact
- Social Impact
- Technical Impact
- Environmental Impact
- Legal Impact
Market Size by Region
- Chart on Market share by geography 2021-2027 (%)
- Data Table on Market share by geography 2021-2027(%)
- North America
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- USA
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Canada
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Europe
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- Germany
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Spain
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- France
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- UK
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of Europe
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Asia Pacific
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- China
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- India
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Japan
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- South Korea
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of Asia Pacific
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Latin America
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- Brazil
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of South America
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Middle East & Africa (MEA)
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- GCC Countries
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- South Africa
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of MEA
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
KEY COMPANY PROFILES
- Competitive Landscape
- Total number of companies covered
- Exhibit: companies covered in the report, 2021
- Top companies market positioning
- Exhibit: company positioning matrix, 2021
- Top companies market Share
- Exhibit: Pie chart analysis on company market share, 2021(%)
- Total number of companies covered
Methodology
For the Bone Graft Substitutes Market, our research methodology involved a mixture of primary and secondary data sources. Key steps involved in the research process are listed below:
1. Information Procurement: This stage involved the procurement of Market data or related information via primary and secondary sources. The various secondary sources used included various company websites, annual reports, trade databases, and paid databases such as Hoover's, Bloomberg Business, Factiva, and Avention. Our team did 45 primary interactions Globally which included several stakeholders such as manufacturers, customers, key opinion leaders, etc. Overall, information procurement was one of the most extensive stages in our research process.
2. Information Analysis: This step involved triangulation of data through bottom-up and top-down approaches to estimate and validate the total size and future estimate of the Bone Graft Substitutes Market.
3. Report Formulation: The final step entailed the placement of data points in appropriate Market spaces in an attempt to deduce viable conclusions.
4. Validation & Publishing: Validation is the most important step in the process. Validation & re-validation via an intricately designed process helped us finalize data points to be used for final calculations. The final Market estimates and forecasts were then aligned and sent to our panel of industry experts for validation of data. Once the validation was done the report was sent to our Quality Assurance team to ensure adherence to style guides, consistency & design.
Analyst Support
Customization Options
With the given market data, our dedicated team of analysts can offer you the following customization options are available for the Bone Graft Substitutes Market:
Product Analysis: Product matrix, which offers a detailed comparison of the product portfolio of companies.
Regional Analysis: Further analysis of the Bone Graft Substitutes Market for additional countries.
Competitive Analysis: Detailed analysis and profiling of additional Market players & comparative analysis of competitive products.
Go to Market Strategy: Find the high-growth channels to invest your marketing efforts and increase your customer base.
Innovation Mapping: Identify racial solutions and innovation, connected to deep ecosystems of innovators, start-ups, academics, and strategic partners.
Category Intelligence: Customized intelligence that is relevant to their supply Markets will enable them to make smarter sourcing decisions and improve their category management.
Public Company Transcript Analysis: To improve the investment performance by generating new alpha and making better-informed decisions.
Social Media Listening: To analyze the conversations and trends happening not just around your brand, but around your industry as a whole, and use those insights to make better Marketing decisions.
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