USD 6.39 Billion
Gene Therapy Market Size, Share, Growth Analysis, By Type (Gene Silencing, Cell Replacement, Gene Augmentation), By Vector (Viral Vectors, Non-Viral Vectors), By Therapeutic Area (Neurology, Oncology, Hepatology), By Delivery Mode (IN VIVO, EX VIVO), By Route Of Administration, By Region - Industry Forecast 2025-2032
Report ID:
SQMIG35H2218 |
Region:
Global |
Published Date: September, 2024
Pages:
157
|Tables:
73
|Figures:
75
Gene Therapy Market Insights
Gene Therapy Market size was valued at USD 9 Billion in 2023 and is poised to grow from USD 10.93 Billion in 2024 to USD 51.55 Billion by 2032, growing at a CAGR of 21.4% during the forecast period (2025-2032).
The global gene therapy market is being facilitated by rising healthcare costs, the existence of cutting-edge healthcare facilities, and the availability of reimbursements. Nonetheless, during the projected future, it is anticipated that the high cost of gene therapies will partially restrain market expansion. One particular subset of these comes in the form of genes. Gene therapy serves as an advanced way to treat diseases like blood disorders, cancer, infections and chronic illnesses. For instance, through gene therapy, patients can have their malfunctioning genes replaced entirely or in part with normal ones to cure them from or halt the transmission of a disease.
There are two different kinds of gene therapy:
Somatic gene therapy and germline gene therapy. Somatic gene therapy is for treating diseases that can be achieved by adding genes to specific cells in the body, such as AIDS, cancer, Parkinson’s disease or cystic fibrosis; while germline gene therapy targets the DNA on chromosomes found in reproductive cells. Biological vectors like viruses, liposomes, and plasmids are used to introduce the transgene into the host cell. These vectors are further divided into non-viral and viral categories. The components of the viral vector are the lentivirus, adenovirus, retrovirus, and adeno-associated vector. Liposomes, transposons, and plasmids are components of the non-viral vector.
US Gene Therapy Market is poised to grow at a sustainable CAGR for the next forecast year.
Market snapshot - 2025-2032
Global Market Size
Largest Segment
Retrovirus & gamma Retrovirus
Fastest Growth
Retrovirus & gamma Retrovirus
Growth Rate
19% CAGR
Global Gene Therapy Market ($ Bn)
Country Share by North America (%)
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Gene Therapy Market Segmental Analysis
Global Gene Therapy Market is segmented on the basis of type, vector, therapeutic area, route of administration, delivery mode, and region. By type, market is segmented into gene silencing, cell replacement, gene augmentation, other therapies. By vector, market is segmented into viral vectors, and non-viral vectors. By therapeutic area, market is segmented into Neurology, Oncology, Hepatology, and Other Therapeutic areas. By route of administration, market is segmented into intravenous, and other routes of administration. By delivery method, gene therapy market is segmented into IN VIVO, and EX VIVO. By region, the market is segmented into North America, Europe, Asia Pacific, Middle East and Africa, and Latin America.
Gene Therapy Market Analysis by Vector Type
As per categorization by vector type, the market is classified as viral vector and non-viral vector. Among these, non-viral vector earned the largest share and continues to dominate the market. Non-viral vectors are revolutionizing the global gene therapy industry due to their safety profile, ease of production, and minimal risk of insertional mutagenesis. Including the latest nanoparticle compositions and better administration methods, the non-viral drugs are becoming more preferred due to their lower chances of arousing the immune system and easier scalability; hence they rule the market.
Viral vectors are poised to be the fastest-growing segment in the global gene therapy market size due to their highly efficient gene delivery capabilities and ability to target specific cells with precision. The adoption of vector engineering is enhanced by the advances in safety profiles and targeted delivery systems. In addition, they are further accelerated in market growth by their proven success in clinical trials for treating genetic disorders and cancers, as they provide strong and long-lasting therapeutic effects.
Gene Therapy Market Analysis by Therapy
In vivo gene therapy industry is evolving amidst breakthroughs in targeted delivery systems and better vector technology, thereby enhancing therapeutic effectiveness right inside the patient’s body. The leading solutions in this market are non-viral vectors that have better safety profiles, less likelihood of immune responses, and simpler manufacturing processes leading to more extensive clinical applications.
Gene therapy involving ex vivo applications is moving quickly due to its capacity for exact cell alterations before being put back in the body, which helps in controlling the treatment better while reducing misdirection. The modernization of cell engineering and manufacturing methodologies is making this approach more effective and safer. More clinical trials are being carried out supporting its success in curing intricate genetic problems and tumors thus leading to its adoption as a suitable alternative for tailored gene therapies.
Global Gene Therapy Market By Vector Type (%)
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Gene Therapy Market Regional Insights
North America dominates the global gene therapy market size due to its robust infrastructure, substantial investment in research and development, and leading biotech and pharmaceutical companies. The region gets advanced health care systems, top-notch research institutions, while a favorably regulated environment helps spur innovation and hasten clinical trials. High expenditure on healthcare and the growing focus on personalized medicine are driving gene therapy market growth. North America’s leadership in gene therapies is reinforced by major actors in the market and favorable reimbursement policies that make it the leader in terms of gene therapy market progress.
Due to its rapidly expanding healthcare infrastructure, increasing investment in biotechnology, and a growing population of patients with genetic disorders, the Asia-Pacific region is rapidly growing for global gene therapy market purposes. A favorable environment to perform various genetic research has been established through extensive diversity of genetic resources on one hand side while higher chances of clinical trials are increasing in number as medical technology progresses forward. Economic growth combined with focus on improving medical technologies as well as expanding access to healthcare has consequently led to innovations and acceptance of gene therapies. Moreover, the rapid growth of the pharmaceutical industry in Asia-Pacific region is further aided by government support policies.
Global Gene Therapy Market By Geography
- Largest
- Fastest
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Gene Therapy Market Dynamics
Gene Therapy Market Drivers
CRISPR-Cas9 Propelling Market Growth:
- The burgeoning global gene therapy industry is propelled by rapid advancements in gene editing technologies such as CRISPR-Cas9. By improving the accuracy, efficacy and safety of genetic manipulation, these state-of-the-art technologies have expedited clinical development steps and increased the number of options available for patients. In addition, vector-based approaches alongside better delivery systems are aiding this growth.
Rising Prevalence of Genetic Disorders:
- Infectious diseases which are rare and genetic deformities are one key factor fueling the global gene therapy market. As levels of awareness and diagnostic abilities go up, the demand for new medication increases. The industry’s prosperity and research investment is spurred by the hope of gene therapy to cure once incurable conditions.
Restraints
Ethical and Safety Concerns:
- The expansion of the global gene therapy industry may be hampered by several issues such as long-term hazards, off-target consequences and other ethical and safety concerns. New therapies may not gain traction among the public or regulators and could hinder investment as well as market growth due to fears about genetic engineering.
Limited Reimbursement Policies:
- There are considerable payment systems as well as their limitations and unevenness which hinder gene therapies. To patients, the cost and accessibility of many gene therapies are expensive with no complete coverage from either health systems or insurance companies. This uncertainty in reimbursement can dissuade investments and inhibit market uptake.
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Gene Therapy Market Competitive Landscape
Numerous key players are driving innovation and market growth in the competitive global gene therapy market. Leading companies include Novartis, who offer Kymriah; Gilead Sciences, with its Yescarta; and Bluebird Bio, which focuses on therapies for genetic diseases. Apart from these, other noteworthy entities are Spark Therapeutics and CRISPR Therapeutics involved in advances in gene editing and delivery technologies. The R&D activities of these firms are intensive aimed at increasing the range of therapeutic indications as well as consolidating their position in the marketplace.
Gene Therapy Market Top Player’s Company Profiles
- Novartis AG (Switzerland)
- Biogen Inc. (US)
- Gilead Sciences, Inc. (US)
- Bristol-Myers Squibb (US)
- Alnylam Pharmaceuticals, Inc. (US)
- Sarepta Therapeutics, Inc. (US)
- Amgen, Inc. (US)
- Orchard Therapeutics PLC (UK)
- F. Hoffmann-La Roche AG (Switzerland)
- Jazz Pharmaceuticals PLC (Ireland)
- uniQure N.V. (Netherlands)
- Johnson & Johnson (US)
- bluebird bio, Inc. (US)
- BioMarin Pharmaceutical Inc. (US)
- Krystal Biotech, Inc. (US)
- Shanghai Sunway Biotech Co. Ltd. (China)
- Sibiono Genetech Co. Ltd. (China)
- Ferring B.V. (Netherlands)
- Vertex Pharmaceuticals Incorporated (US)
- Pfizer Inc. (US)
- Sangamo Therapeutics, Inc. (US)
- Regenxbio (US)
- Ultragenyx Pharmaceutical Inc. (US)
- MeiraGTx Holdings PLC (UK)
- AnGes, Inc. (Japan)
Recent Developments in Gene Therapy Industry
- In July 2022, Novartis Pharmaceuticals UK announces the launch of the Novartis Biome UK Heart Health Catalyst 2022, in a world-first investor partnership with Medtronic ltd, RYSE Asset Management, and Chelsea and Westminster Hospital NHS Foundation Trust and its official charity CW+
- In March 2022, the National Heart Lung and Blood Institute granted USD 12 million to an Indiana University School of Medicine researcher. The grant is for exploring major themes in a gene therapy approach to safer and potentially curative treatments for hemophilia.
- In August 2021, Spark Therapeutics announced that it had completed its acquisition by Roche for $4.3 billion. Spark Therapeutics is known for developing the first FDA-approved gene therapy, Luxturna, for an inherited retinal disease.
- In July 2021, the European Commission approved Novartis' gene therapy Zolgensma for the treatment of patients with SMA, making it the second approved gene therapy for SMA in Europe after Biogen's Spinraza.
Gene Therapy Key Market Trends
Transforming the Gene Therapy Landscape:
- The global gene therapy industry is changing because of innovations, advances in genetic research, and growing knowledge of gene-based treatments. Targets for gene therapy are increasingly rare hereditary disorders. As genetic defects causing diseases are identified, gene cures for rare conditions are being created. Those with incurable illnesses now have hope due to the advancement towards more targeted and accurate therapies.
Rise of Gene Therapy and CAR T-Cell Innovations in Cancer Treatment:
- The market for oncology gene therapy is expanding. Scientists are looking into gene-based strategies to attack cancer cells while safeguarding healthy organs. One of the most promising approaches to advance cancer therapy is chimeric antigen receptor (CAR) T-cell therapies. They have already proved useful in treating hematological malignancies.
Gene Therapy Market SkyQuest Analysis
SkyQuest’s ABIRAW (Advanced Business Intelligence, Research & Analysis Wing) is our Business Information Services team that Collects, Collates, Correlates, and Analyses the Data collected by means of Primary Exploratory Research backed by robust Secondary Desk research.
As per SkyQuest analysis, At the end we can see that Global gene therapy market has promising job opportunities. This is mainly due to developments in genetic studies, growing cognizance of gene-related medication and escalating funding towards health services. Nevertheless, some roadblocks include expensive treatments and questions on morality, but this field continues to grow through introduction of new technologies like the CRISPR-Cas9 system plus CAR T-cell therapy.
These advancements offer new hope for treating previously incurable diseases, including rare genetic disorders and various cancers. As both viral and non-viral vectors evolve, and regions like North America and Asia-Pacific push research and development, gene therapy promises transformative healthcare solutions worldwide.
| Report Metric | Details |
|---|---|
| Market size value in 2023 | USD 9 Billion |
| Market size value in 2032 | USD 51.55 Billion |
| Growth Rate | 21.4% |
| Base year | 2024 |
| Forecast period | 2025-2032 |
| Forecast Unit (Value) | USD Billion |
| Segments covered |
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| Regions covered | North America (US, Canada), Europe (Germany, France, United Kingdom, Italy, Spain, Rest of Europe), Asia Pacific (China, India, Japan, Rest of Asia-Pacific), Latin America (Brazil, Rest of Latin America), Middle East & Africa (South Africa, GCC Countries, Rest of MEA) |
| Companies covered |
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| Customization scope | Free report customization with purchase. Customization includes:-
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Table Of Content
Executive Summary
Market overview
- Exhibit: Executive Summary – Chart on Market Overview
- Exhibit: Executive Summary – Data Table on Market Overview
- Exhibit: Executive Summary – Chart on Gene Therapy Market Characteristics
- Exhibit: Executive Summary – Chart on Market by Geography
- Exhibit: Executive Summary – Chart on Market Segmentation
- Exhibit: Executive Summary – Chart on Incremental Growth
- Exhibit: Executive Summary – Data Table on Incremental Growth
- Exhibit: Executive Summary – Chart on Vendor Market Positioning
Parent Market Analysis
Market overview
Market size
- Market Dynamics
- Exhibit: Impact analysis of DROC, 2021
- Drivers
- Opportunities
- Restraints
- Challenges
- Exhibit: Impact analysis of DROC, 2021
- SWOT Analysis
KEY MARKET INSIGHTS
- Technology Analysis
- (Exhibit: Data Table: Name of technology and details)
- Pricing Analysis
- (Exhibit: Data Table: Name of technology and pricing details)
- Supply Chain Analysis
- (Exhibit: Detailed Supply Chain Presentation)
- Value Chain Analysis
- (Exhibit: Detailed Value Chain Presentation)
- Ecosystem Of the Market
- Exhibit: Parent Market Ecosystem Market Analysis
- Exhibit: Market Characteristics of Parent Market
- IP Analysis
- (Exhibit: Data Table: Name of product/technology, patents filed, inventor/company name, acquiring firm)
- Trade Analysis
- (Exhibit: Data Table: Import and Export data details)
- Startup Analysis
- (Exhibit: Data Table: Emerging startups details)
- Raw Material Analysis
- (Exhibit: Data Table: Mapping of key raw materials)
- Innovation Matrix
- (Exhibit: Positioning Matrix: Mapping of new and existing technologies)
- Pipeline product Analysis
- (Exhibit: Data Table: Name of companies and pipeline products, regional mapping)
- Macroeconomic Indicators
COVID IMPACT
- Introduction
- Impact On Economy—scenario Assessment
- Exhibit: Data on GDP - Year-over-year growth 2016-2022 (%)
- Revised Market Size
- Exhibit: Data Table on Gene Therapy Market size and forecast 2021-2027 ($ million)
- Impact Of COVID On Key Segments
- Exhibit: Data Table on Segment Market size and forecast 2021-2027 ($ million)
- COVID Strategies By Company
- Exhibit: Analysis on key strategies adopted by companies
MARKET DYNAMICS & OUTLOOK
- Market Dynamics
- Exhibit: Impact analysis of DROC, 2021
- Drivers
- Opportunities
- Restraints
- Challenges
- Exhibit: Impact analysis of DROC, 2021
- Regulatory Landscape
- Exhibit: Data Table on regulation from different region
- SWOT Analysis
- Porters Analysis
- Competitive rivalry
- Exhibit: Competitive rivalry Impact of key factors, 2021
- Threat of substitute products
- Exhibit: Threat of Substitute Products Impact of key factors, 2021
- Bargaining power of buyers
- Exhibit: buyers bargaining power Impact of key factors, 2021
- Threat of new entrants
- Exhibit: Threat of new entrants Impact of key factors, 2021
- Bargaining power of suppliers
- Exhibit: Threat of suppliers bargaining power Impact of key factors, 2021
- Competitive rivalry
- Skyquest special insights on future disruptions
- Political Impact
- Economic impact
- Social Impact
- Technical Impact
- Environmental Impact
- Legal Impact
Market Size by Region
- Chart on Market share by geography 2021-2027 (%)
- Data Table on Market share by geography 2021-2027(%)
- North America
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- USA
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Canada
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Europe
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- Germany
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Spain
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- France
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- UK
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of Europe
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Asia Pacific
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- China
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- India
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Japan
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- South Korea
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of Asia Pacific
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Latin America
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- Brazil
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of South America
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Middle East & Africa (MEA)
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- GCC Countries
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- South Africa
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of MEA
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
KEY COMPANY PROFILES
- Competitive Landscape
- Total number of companies covered
- Exhibit: companies covered in the report, 2021
- Top companies market positioning
- Exhibit: company positioning matrix, 2021
- Top companies market Share
- Exhibit: Pie chart analysis on company market share, 2021(%)
- Total number of companies covered
Methodology
For the Gene Therapy Market, our research methodology involved a mixture of primary and secondary data sources. Key steps involved in the research process are listed below:
1. Information Procurement: This stage involved the procurement of Market data or related information via primary and secondary sources. The various secondary sources used included various company websites, annual reports, trade databases, and paid databases such as Hoover's, Bloomberg Business, Factiva, and Avention. Our team did 45 primary interactions Globally which included several stakeholders such as manufacturers, customers, key opinion leaders, etc. Overall, information procurement was one of the most extensive stages in our research process.
2. Information Analysis: This step involved triangulation of data through bottom-up and top-down approaches to estimate and validate the total size and future estimate of the Gene Therapy Market.
3. Report Formulation: The final step entailed the placement of data points in appropriate Market spaces in an attempt to deduce viable conclusions.
4. Validation & Publishing: Validation is the most important step in the process. Validation & re-validation via an intricately designed process helped us finalize data points to be used for final calculations. The final Market estimates and forecasts were then aligned and sent to our panel of industry experts for validation of data. Once the validation was done the report was sent to our Quality Assurance team to ensure adherence to style guides, consistency & design.
Analyst Support
Customization Options
With the given market data, our dedicated team of analysts can offer you the following customization options are available for the Gene Therapy Market:
Product Analysis: Product matrix, which offers a detailed comparison of the product portfolio of companies.
Regional Analysis: Further analysis of the Gene Therapy Market for additional countries.
Competitive Analysis: Detailed analysis and profiling of additional Market players & comparative analysis of competitive products.
Go to Market Strategy: Find the high-growth channels to invest your marketing efforts and increase your customer base.
Innovation Mapping: Identify racial solutions and innovation, connected to deep ecosystems of innovators, start-ups, academics, and strategic partners.
Category Intelligence: Customized intelligence that is relevant to their supply Markets will enable them to make smarter sourcing decisions and improve their category management.
Public Company Transcript Analysis: To improve the investment performance by generating new alpha and making better-informed decisions.
Social Media Listening: To analyze the conversations and trends happening not just around your brand, but around your industry as a whole, and use those insights to make better Marketing decisions.
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