USD 4.81 billion
Genome Editing Market Size, Share, Growth Analysis, By Technology((CRISPR)/Cas9, TALENs/MegaTALs, ZFN, Meganuclease), By Delivery Method(Ex-vivo, In-vivo), By Application(Genetic Engineering [Cell Line Engineering, Animal Genetic Engineering, Plant Genetic Engineering, Others]), By Mode(Contract, In-house), By End-Use(Biotechnology and Pharmaceutical Companies, Academic and Government Research Institutes, Contract Research Organizations), By Region - Industry Forecast 2024-2031
Report ID:
SQSG35J2001 |
Region:
Global |
Published Date: September, 2024
Pages:
157
|Tables:
117
|Figures:
77
Genome Editing Market Insights
Global Genome Editing Market size was valued at USD 7.70 billion in 2022 and is poised to grow from USD 8.99 billion in 2023 to USD 31.15 billion by 2031, growing at a CAGR of 16.80% during the forecast period (2024-2031).
The market is characterized by moderate merger and acquisition activity by many industry players. This is due to several factors including the desire to gain a competitive advantage in the industry. For example, in January 2024, Ginkgo Bioworks launched market that it has acquired Proof Diagnostics, expanding Ginkgo's portfolio of products into medical genetics repair tools.
Positive government regulations on synthetic organisms, increasing demand for genes and synthetic cells, and heavy investments by governments and large corporations have driven the growth of the market. Various unconventional strategies for editing and exploiting discovered genes is an important new development in gene therapy and molecular biology.
Large players are adopting this strategy to increase their productivity and marketability and improve their product availability in various geographies. In addition, specialized strategies to raise awareness among students and increase educational materials are expected to boost the genome editing market. For example, in March 2024 Carolina Biological Supply Company and Christianacare Gene Editing Institute worked 9 to 12 Developed exclusive CRISPR in Box educational kit for upper grades and university, offering hands-on instruction in CRISPR techniques.
US Genome Editing Market is poised to grow at a sustainable CAGR for the next forecast year.
Market Snapshot - 2024-2031
Global Market Size
Largest Segment
CRISPR
Fastest Growth
CRISPR
Growth Rate
22.3% CAGR
Global Genome Editing Market ($ Bn)
Country Share for North America Region (%)
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Genome Editing Market Segmental Analysis
Global Genome Editing Market is segmented by Technology, Delivery Method, Application, Mode, End-use, and region. Based on Technology, the market is segmented into (CRISPR)/Cas9, TALENs/MegaTALs, ZFN, Meganuclease, and Others. Based on Delivery Method, the market is segmented into Ex-vivo, and In-Vivo. Based on Application, the market is segmented into Genetic Engineering, and Clinical Applications. Based on Mode, the market is segmented into Contract, and In-house. Based on end use, the market is segmented into Biotechnology and pharmaceutical companies, Academic and government research institutes, and Contract research organizations. Based on region, the market is segmented into North America, Europe, Asia Pacific, Latin America and Middle East & and Africa.
Genome Editing Market Analysis by Delivery Method
The ex-vivo segment dominated the market with a 51.24% share in 2023. This dominance can be attributed to the ease of controlling delivery of DNA modifications with precise regulation of the intensity and duration of nuclease expression to improve efficiency. Ex-vivo products such as CAR-T technology for the treatment of oncology hematology appear to be prioritized in the molecular scissors pipeline. At the ex-vivo stage, genes are modified outside the patient’s body, usually in isolated cells, before being transplanted back in. This approach has many advantages in the genome modification market, in the field of medicine. Ex-vivo editing allows cells to be processed under controlled laboratory conditions, ensuring high accuracy and reducing off-target effects.
The in-vivo segment is expected to witness rapid growth at a CAGR of 19.94% between 2024 and 2030. Many specialized cell types cannot be isolated from the patient and kept alive during the long posttransplant period of treatment, or they are not efficiently returned to the patient after treatment. Thus, the development of more in-vivo genome editing techniques is expected to boost the market growth soon. In the in-vivo phase, genes are exchanged directly in the host. This approach is advanced and revolutionary, which can treat genetic diseases at the root cause without the need for cell extraction.
In vivo gene editing aims to correct genetic mutations in patients’ tissues or organs. For diseases such as muscle dysfunction or liver-related genetic conditions, CRISPR-Cas9 or other gene editing tools are delivered via vectors into tissues involved directly, enabling precise gene correction in situ.
Analysis by Technology
The CRISPR/Cas9 segment held the largest market share of 43.52% in terms of global revenue in 2023. This can be attributed to high accuracy & efficiency, high versatility & adaptability to various experimental designs, and relatively low cost. CRISPR has been widely accepted for clinical use. This is reflected in the ongoing clinical trials using gene editing techniques to treat a wide range of diseases such as AIDS, cancer and genetic diseases. In addition to human health, technology is playing an increasing role in agricultural and animal breeding experiments.
The ZFN segment is expected to witness a significant CAGR of 16.56% during the forecast period. Zinc finger nuclease (ZFN) is a widely used genome editing technology. It is an optimized version of a nucleus that facilitates the modification of target DNA strands. ZFN or endonucleases have been successfully used to target HBV, HIV, human papillomavirus, herpes simplex virus types, and human T-cell leukemia virus types, as these are susceptible to transcriptional repression and gene degradation by ZFN. Also, lower off-target activity as treatment really helps approved ZFNs. Consequently, the approach is expected to have significant economic relevance for gene therapy in the coming years.
Global Genome Editing Market By Technology (%)
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Genome Editing Market Regional Insights
North America is dominated the genome editing market, accounting for 47.81% in 2023 due to rising investments in R&D of gene editing technologies. Several biotechnologies and the pharmaceutical companies operating in the genome editing technology are estimated to remain dominant over the forecast period. Availability of strong research infrastructure, rise in genetically modified crops, high genetic diseases inherited diseases are common. In other words, the number of licenses issued by U.S-based firms. Increased supply has also accelerated the development of genome editing tools in the country, leading to positive market growth.
Asia Pacific is expected to witness fastest growth at 18.75% CAGR between 2024 and 2030. Also attracting investment and finance from domestic companies providing gene editing products and services. For example, in April 2021, GeneScript launched a Research-Grade Lentiviral Vector Packaging Service for drug discovery, cell line manufacturing and gene editing. The company is developing initiatives to promote genome engineering services such as CRISPR services and gene services. The growth of the nearby market is anticipated to be driven by the increasing demand for for gene modifying technology and growing incidence of genetic sicknesses and illnesses in countries such as India and Australia.
Global Genome Editing Market By Geography
- Largest
- Fastest
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Genome Editing Market Dynamics
Genome Editing Market Driver
Growing Demand for Precision Pharmaceuticals
- Genome editing is gaining popularity in agriculture, where it can be used to produce crops with improved traits such as drought tolerance, pest resistance and improved nutrition Agriculture is expected to play an important role in the future genome editing technological advances. CRISPR technology has improved crops rapidly in this market.
Technological Advances in Gene Editing Tools
- Technological innovations are accelerating the adoption of genome editing. CRISPR-Cas9, a commonly used tool, has revolutionized the field because of its simplicity, accuracy and affordability. In addition, new equipment along with the base editors and prime editors are imparting more accuracy, reducing off-target results, and increasing the applicability of genome editing in medicine and agriculture.
Restraints
Ethical and Legal Challenges
- Ethical concerns about genome editing continue to pose significant challenges, particularly in human embryos and bacterial cells. While guided by using these regulatory conditions, approval of genome enhancing treatment plans, hampering marketplace growth. These issues have caused stringent guidelines in many nations, slowing down research and development.
Off-target Effects and Safety Concerns
- One of the biggest technical hurdles in genome editing is off-target effects, which include unintended changes in the genome. These unintended changes can lead to deleterious mutations, raising concerns about the safety of genome editing therapies. This uncertainty, especially in clinical applications, remains a major barrier to the adoption of genome modification in human medicine.
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Genome Editing Market Competitive Landscape
One of the most important technical hurdles in genome editing is off-goal consequences, which encompass unintentional adjustments inside the genome. This uncertainty, mainly in the clinical applications, remains a barrier to the adoption of genome change in human medication. These unintended modifications can result in deleterious mutations, raising concerns about the safety of the genome enhancing cures.
Genome Editing Market Top Players Company Profiles
- Merck KGaA (Germany)
- Cibus Inc (US)
- Recombinetics (US)
- Sangamo Therapeutics (US)
- Editas Medicine (US)
- Precision BioSciences (US)
- CRISPR Therapeutics (Switzerland)
- Intellia Therapeutics, Inc (US)
- Caribou Biosciences, Inc. (US)
- Cellectis S.A (France)
- AstraZeneca (UK)
- Takara Bio Inc. (Japan)
- Horizon Discovery Ltd. (Revvity, Inc.) (UK)
- Danaher Corporation (US)
- Transposagen Biopharmaceuticals, Inc. (US)
- Genscript Biotech Corp (China)
- New England Biolabs (US)
- OriGene Technologies, Inc. (US)
- bluebird bio, Inc (US)
- Lonza (Switzerland)
- Thermo Fisher Scientific Inc. (US)
Genome Editing Market Recent Developments
- In January 2024, Danaher Corporation partnered with the Innovative Genomics Institute (IGI).
- In November 2023, Selectis signed a collaboration agreement with AstraZeneca to accelerate the development of advanced therapies in oncology and immunology.
- In July 2023, Sangamo Therapeutics partnered with Chroma Medicine to develop epigenetic drugs using Sangamo’s zinc finger proteins (ZFPs).
Genome Editing Key Market Trends
- Growing Application in Agriculture: Genome editing is gaining popularity in agriculture, where it is used to produce crops with improved traits such as drought tolerance, pest resistance and improved nutrition. CRISPR technology has enabled rapid crop improvement, which is exactly, making it a leading trend in this market. Agriculture is expected to play an important role in the future development of genome editing technologies as global food security concerns rise.
- Expansion of Ex-Vivo and In-Vivo Therapies: Both ex-vivo (extracorporeal cell editing) and in-vivo (internal cell editing) gene editing is expanding rapidly. Ex-vivo therapies in areas such as CAR-T cell therapy for cancer have gained momentum, while in-vivo applications in the treatment of diseases such as vascular dysfunction and liver disease. The increasing number of clinical trials examining both approaches highlights the growing interest and market potential in these treatment areas.
Genome Editing Market SkyQuest Analysis
SkyQuest’s ABIRAW (Advanced Business Intelligence, Research & Analysis Wing) is our Business Information Services team that Collects, Collates, Correlates, and Analyses the Data collected by means of Primary Exploratory Research backed by robust Secondary Desk research.
According to SkyQuest analysis, the genome editing market is developing hastily, pushed by the demand for precision medication and advances in gene editing equipment which includes CRISPR. This technology is changing the remedy approach for genetic illnesses, cancers and rare problems, and new rising opportunities in agriculture. Despite the capacity, the marketplace faces sizeable challenges such as ethical and regulatory issues, as well as safety concerns related to off target consequences. These elements might also drive uptake of genome editing healing procedures, particularly in human medicinal drug.
| Report Metric | Details |
|---|---|
| Market size value in 2022 | USD 7.70 billion |
| Market size value in 2031 | USD 31.15 billion |
| Growth Rate | 16.80% |
| Base year | 2023 |
| Forecast period | 2024-2031 |
| Forecast Unit (Value) | USD Billion |
| Segments covered |
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| Regions covered | North America (US, Canada), Europe (Germany, France, United Kingdom, Italy, Spain, Rest of Europe), Asia Pacific (China, India, Japan, Rest of Asia-Pacific), Latin America (Brazil, Rest of Latin America), Middle East & Africa (South Africa, GCC Countries, Rest of MEA) |
| Companies covered |
|
| Customization scope | Free report customization with purchase. Customization includes:-
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Table Of Content
Executive Summary
Market overview
- Exhibit: Executive Summary – Chart on Market Overview
- Exhibit: Executive Summary – Data Table on Market Overview
- Exhibit: Executive Summary – Chart on Genome Editing Market Characteristics
- Exhibit: Executive Summary – Chart on Market by Geography
- Exhibit: Executive Summary – Chart on Market Segmentation
- Exhibit: Executive Summary – Chart on Incremental Growth
- Exhibit: Executive Summary – Data Table on Incremental Growth
- Exhibit: Executive Summary – Chart on Vendor Market Positioning
Parent Market Analysis
Market overview
Market size
- Market Dynamics
- Exhibit: Impact analysis of DROC, 2021
- Drivers
- Opportunities
- Restraints
- Challenges
- Exhibit: Impact analysis of DROC, 2021
- SWOT Analysis
KEY MARKET INSIGHTS
- Technology Analysis
- (Exhibit: Data Table: Name of technology and details)
- Pricing Analysis
- (Exhibit: Data Table: Name of technology and pricing details)
- Supply Chain Analysis
- (Exhibit: Detailed Supply Chain Presentation)
- Value Chain Analysis
- (Exhibit: Detailed Value Chain Presentation)
- Ecosystem Of the Market
- Exhibit: Parent Market Ecosystem Market Analysis
- Exhibit: Market Characteristics of Parent Market
- IP Analysis
- (Exhibit: Data Table: Name of product/technology, patents filed, inventor/company name, acquiring firm)
- Trade Analysis
- (Exhibit: Data Table: Import and Export data details)
- Startup Analysis
- (Exhibit: Data Table: Emerging startups details)
- Raw Material Analysis
- (Exhibit: Data Table: Mapping of key raw materials)
- Innovation Matrix
- (Exhibit: Positioning Matrix: Mapping of new and existing technologies)
- Pipeline product Analysis
- (Exhibit: Data Table: Name of companies and pipeline products, regional mapping)
- Macroeconomic Indicators
COVID IMPACT
- Introduction
- Impact On Economy—scenario Assessment
- Exhibit: Data on GDP - Year-over-year growth 2016-2022 (%)
- Revised Market Size
- Exhibit: Data Table on Genome Editing Market size and forecast 2021-2027 ($ million)
- Impact Of COVID On Key Segments
- Exhibit: Data Table on Segment Market size and forecast 2021-2027 ($ million)
- COVID Strategies By Company
- Exhibit: Analysis on key strategies adopted by companies
MARKET DYNAMICS & OUTLOOK
- Market Dynamics
- Exhibit: Impact analysis of DROC, 2021
- Drivers
- Opportunities
- Restraints
- Challenges
- Exhibit: Impact analysis of DROC, 2021
- Regulatory Landscape
- Exhibit: Data Table on regulation from different region
- SWOT Analysis
- Porters Analysis
- Competitive rivalry
- Exhibit: Competitive rivalry Impact of key factors, 2021
- Threat of substitute products
- Exhibit: Threat of Substitute Products Impact of key factors, 2021
- Bargaining power of buyers
- Exhibit: buyers bargaining power Impact of key factors, 2021
- Threat of new entrants
- Exhibit: Threat of new entrants Impact of key factors, 2021
- Bargaining power of suppliers
- Exhibit: Threat of suppliers bargaining power Impact of key factors, 2021
- Competitive rivalry
- Skyquest special insights on future disruptions
- Political Impact
- Economic impact
- Social Impact
- Technical Impact
- Environmental Impact
- Legal Impact
Market Size by Region
- Chart on Market share by geography 2021-2027 (%)
- Data Table on Market share by geography 2021-2027(%)
- North America
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- USA
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Canada
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Europe
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- Germany
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Spain
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- France
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- UK
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of Europe
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Asia Pacific
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- China
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- India
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Japan
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- South Korea
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of Asia Pacific
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Latin America
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- Brazil
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of South America
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Middle East & Africa (MEA)
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- GCC Countries
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- South Africa
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of MEA
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
KEY COMPANY PROFILES
- Competitive Landscape
- Total number of companies covered
- Exhibit: companies covered in the report, 2021
- Top companies market positioning
- Exhibit: company positioning matrix, 2021
- Top companies market Share
- Exhibit: Pie chart analysis on company market share, 2021(%)
- Total number of companies covered
Methodology
For the Genome Editing Market, our research methodology involved a mixture of primary and secondary data sources. Key steps involved in the research process are listed below:
1. Information Procurement: This stage involved the procurement of Market data or related information via primary and secondary sources. The various secondary sources used included various company websites, annual reports, trade databases, and paid databases such as Hoover's, Bloomberg Business, Factiva, and Avention. Our team did 45 primary interactions Globally which included several stakeholders such as manufacturers, customers, key opinion leaders, etc. Overall, information procurement was one of the most extensive stages in our research process.
2. Information Analysis: This step involved triangulation of data through bottom-up and top-down approaches to estimate and validate the total size and future estimate of the Genome Editing Market.
3. Report Formulation: The final step entailed the placement of data points in appropriate Market spaces in an attempt to deduce viable conclusions.
4. Validation & Publishing: Validation is the most important step in the process. Validation & re-validation via an intricately designed process helped us finalize data points to be used for final calculations. The final Market estimates and forecasts were then aligned and sent to our panel of industry experts for validation of data. Once the validation was done the report was sent to our Quality Assurance team to ensure adherence to style guides, consistency & design.
Analyst Support
Customization Options
With the given market data, our dedicated team of analysts can offer you the following customization options are available for the Genome Editing Market:
Product Analysis: Product matrix, which offers a detailed comparison of the product portfolio of companies.
Regional Analysis: Further analysis of the Genome Editing Market for additional countries.
Competitive Analysis: Detailed analysis and profiling of additional Market players & comparative analysis of competitive products.
Go to Market Strategy: Find the high-growth channels to invest your marketing efforts and increase your customer base.
Innovation Mapping: Identify racial solutions and innovation, connected to deep ecosystems of innovators, start-ups, academics, and strategic partners.
Category Intelligence: Customized intelligence that is relevant to their supply Markets will enable them to make smarter sourcing decisions and improve their category management.
Public Company Transcript Analysis: To improve the investment performance by generating new alpha and making better-informed decisions.
Social Media Listening: To analyze the conversations and trends happening not just around your brand, but around your industry as a whole, and use those insights to make better Marketing decisions.
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