USD 52.53 Billion
Organ on Chip Market Size, Share, Growth Analysis, By Organ Type(Liver, Kidney, Lungs, Heart), By Application(Drug-discovery, Disease Modelling, and Toxicity Testing), By End-User(Biotech &Pharma Companies, Contract Research Organisations and Academic & Research Institutes.), By Region - Industry Forecast 2024-2031
Report ID:
SQMIG35A2896 |
Region:
Global |
Published Date: May, 2024
Pages:
219
|Tables:
92
|Figures:
76
Organ on Chip Market Insights
Global Organ on Chip Market size was valued at USD 52.53 Billion in 2022 and is poised to grow from USD 68.63 Billion in 2023 to USD 448.92 Billion by 2031, growing at a CAGR of 30.76% during the forecast period (2024-2031).
An organ-on-a-chip is a microfluidic cell culture device that contains continuously perfused chambers. This chip develops a narrow channel for the blood and airflow in different organs like lungs, gut, liver, heart, and others. These devices offer a wide range of applications like disease modelling, drug designing and toxicity testing. The global organ on chip market can be describe by rapid technological advancements, growing adoption across pharma, biotech and academic sectors as well as increasing fundings and investments in research and developments. For instance, in December 2021, Emulate, Inc., stated that its Brain Chip was sent to the ISS National Lab to study the effects of microgravity on human brain physiology as part of the tissue-chips in space initiative sponsored by the NCATS at NIH and the ISS-NL.
The market is majorly driven by factors such as need for alternatives for animal testing and the need for early detection of drug reactions and toxicity. According to data released by People for the Ethical Treatment of Animals, 3.52 million procedures were performed on animals in the UK in 2018. (PETA). In addition, a 2017 report by the US Department of Agriculture estimated that approximately 792,168 animals were held for experiments or used in them nationwide. In 2018, more than 3.9 million animals in Canada were subjected to research.
Moreover, the organ-on-chip technology is not limited to liver, lungs, kidney, heart etc. Stakeholders in this market are trying thier best and focusing on expanding the organ’s applications and sites with this technology. These gadgets are becoming more and more prevalent in healthcare sectors like in hospitals, clinics and research facilities' which can help in generating detailed research and treatments. The future of drug design will be majorly dependent on this technology due to its widespread use in many industries. And as the result, the adoption of organ-on-chip is expected to grow over the time.
Organ-on-chip companies are launching new products to cater to the needs of the research community. After the Covid-19 pandemic, the demand for the advancements in these technologies have witnessed a huge growth, the government as well as various health organisations are trying to focus on this subject. Based on all these driving factors, the global organ-on-chip market is anticipated to grow at a CAGR of 30.76% during the forecast period.
Market Snapshot - 2024-2031
Global Market Size
Largest Segment
Liver
Fastest Growth
Kidney
Growth Rate
30.76% CAGR
Global Organ on Chip Market ($ Bn)
Country Share for North America Region (%)
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Organ on Chip Market Segmental Analysis
The global organ on chip market is segmented by organ type, application, end-user and region. Based on organ type the market can be segmented into liver, kidney, lungs, heart, brain and others. Based on application, the market is segmented into drug-discovery, disease modelling and toxicity testing. Based on end-user, the market is segmented into pharma and biotech companies, contract research organisation and research and academic institutions. And lastly, based on region, the market is segmented into North America, Europe, Asia Pacific, Middle East and Africa, and Latin America.
Analysis by Organ Type
Based on raw type, the market is divided between many sub segments like liver, kidney, lungs, heart, brain and others. Among them liver-on chip market is dominating. Liver plays a very crucial role in our everyday body metabolism. Liver-on-chip platforms offer several advantages over conventional methods, such as improved predictivity, reduced reliance on animal testing, and the ability to perform high-throughput screening of drug candidates. Liver-on-chip models are used to mimic the physiological conditions including toxicity testing and modelling various drug diseases. It is one of the largest researched and developed platforms with various commercial products present in the market. Liver-on-chip platforms are utilized across various applications, including drug discovery, toxicity testing, disease modelling, and personalized medicine which caters to large part of the medicine market.
The kidney-on-chip segment is experiencing rapid growth within the organ-on-chip market due to the critical role of the kidneys in maintaining homeostasis, excreting waste products, and regulating fluid balance in the body. They replicate the intricate structure and function of the renal system, allowing researchers to study the physiology of kidney, including filtration, reabsorption, secretion, and transport. These platforms offer several advantages over traditional cell culture and animal models, such as improved physiological relevance, higher throughput, and the ability to mimic disease states and drug responses more accurately. The kidney-on-chip market is poised for significant growth as researchers and industry stakeholders continue to invest in technology development, research collaborations, and commercialization efforts.
Analysis by Application
Based on application in the organ-on-chip market involves various purposes. Organ-on-chip platforms are used extensively in drug-discovery, disease modelling and toxicity testing. The drug discovery segment is the largest segment, mainly due to its critical role in pharmaceutical research and development. Organ-on-chip technology has helped the drug discovery process by offering more physiologically relevant models that better mimic human organ function and interaction, compared to traditional in vitro and animal models. These microscale platforms enable researchers to assess drug efficacy, toxicity and safety in a more predictive and cost-effective manner, thus accelerating the drug development timeline and reducing the likelihood of late-stage failures in clinical trials. This segment benefits from the increasing demand for innovative research tools and technologies that can identify promising drug candidates with greater efficiency and accuracy. Additionally, these models also allow the study of complex disease mechanisms, drug interactions and patient-specific responses, facilitating the development of targeted therapies and personalized medicine approaches.
The disease modelling application within the organ-on-chip market is likely the fastest-growing segment. Disease modelling on organ-on-chip platforms has gained significant attraction in recent years due to its potential to enable the understanding of disease mechanisms, identify new therapeutic targets, and facilitate the development of precision medicine approaches. One of the key factors driving the rapid growth of disease modelling on organ-on-chip platforms is the urgent need for more effective research tools and models to study complex diseases and develop targeted treatments. Traditional disease models, such as cell cultures and animal models, often fail to accurately recapitulate the intricate interactions between different cell types, tissues, and environmental factors involved in disease progression. In recent times, patient-specific disease models offer valuable insights into individual variability in disease susceptibility, drug efficacy, and treatment outcomes, paving the way for precision medicine initiatives tailored to the needs of individual patients.
Analysis by End-User
Based on end-user, the market is segmented into pharma and biotech companies, contract research organisation and research and academic institutions.
Pharmaceuticals and biotech companies are significant users of organ-on-chip technology for drug discovery, preclinical testing etc. Pharmaceutical and biotechnology companies stand out as the largest end-user segment in the organ-on-chip market due to their massive investment in R&D activities focusing discovery and development of new drugs and therapies. These companies have resources, expertise and infrastructure dedicated to advance research and discoveries regarding new healthcare solutions. Additionally, these companies collaborate with academic institutions, research organizations, and contract research organizations (CROs) to further validate and optimize the organ-on-chip technology, driving its widespread adoption and commercialization in the pharmaceutical industry.
Whereas the contract research organization (CRO) segment is likely the fastest growing. These organizations provide specialised research services to pharmaceutical, biotechnology and academic institutions. The rapid growth of the CRO segment is mainly due to the increasing demand from pharmaceutical and biotechnology companies for specialized research capabilities, flexible solutions, and cost-effective alternatives to in-house research. CROs play a crucial role in providing access to new and leading technologies and regulatory expertise for organ-on-chip studies, enabling pharmaceutical companies to accelerate drug development timelines, reduce costs, and enhance research efficiency. As long as the pharmaceutical industry continues to use outsourcing as a strategic approach for their drug development, the demand for CRO services, in this market, is expected to grow. Hence, driving the rapid growth of the CRO segment in the organ-on-chip market.
Global Organ on Chip Market By Organ Type
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Organ on Chip Market Regional Insights
North America has traditionally been the largest market for the organ-on-chip technology. It is leading region in the adoption of this tech due to presence of various pharma companies, research institutions and tech developers. This region has a robust environment for biotech and life science which caters to new innovations. Regulatory agencies like FDA engage with the stakeholders to explore the potential use in drug discovery and safety assessments.
However, the Asia-Pacific region has been experiencing a rapid growth in the organ-on-chip market. Specially countries like Japan, China, South Korea and Singapore have been making substantial investments in research and new innovations. The rising demand for personalised medicines and development in healthcare infrastructure as well as presence of large pharmaceutical market further makes it the fastest growing market.
In Europe countries like Germany, Netherlands, UK have emerged as hubs for organ-on-chip research and commercialization. European regulatory agencies like EMA are involved in discussions on regulatory acceptance and validation of organ-on-chip models. More than 60% of the funding has been raised by organ on chip companies based in Europe. Netherlands based organ on a chip company Mimetas has raised the maximum funding during the period captured
Similarly in Latin America, countries like Brazil, Mexico and Argentina as well as in Middle East and Africa, countries like South Africa, Israel and the UAE are investing heavily in biotech innovation and research investments. Collaborative initiatives and partnerships with global stakeholders are essential for accelerating the adoption and implementation of organ-on-chip market.
Global Organ on Chip Market By Region
- Largest
- Fastest
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Organ on Chip Market Dynamics
Drivers
Increase In Demands for Animal Free Testing
- The consumers across the world are rising voices in the favour of animal free testing. With this awareness, the demand for organ on chip platforms have a huge role to play in drug discovery, toxicity testing and many other such things which can give further push to this market.
Increasing Demand for Personalized Medicine Approaches
- The shift towards personalized medicine, which aims to tailor medical treatment to individual patients based on their genetic makeup, disease characteristics, and lifestyle factors, is driving demand for more precise and patient-specific research tools. Organ-on-chip technology helps in creating patient-derived models that reflect individual variability in drug responses and disease susceptibility, which will further help in the development of personalized treatment strategies and targeted therapies.
Restraints
Ethical and Societal Challenges
- Ethical considerations surrounding the use of human cells, tissues, organs in organ-on-chip research raises concerns about informed consent, privacy and ethical sourcing of the biological materials. It is very important to address the ethical. Legal and societal implications, including animal welfare, for responsible and sustainable development of this market.
Cost and Accessibility
- The organ-on-chip technology is very expensive to develop, manufacture and maintain along with limited accessibility for smaller research labs, academic institutions and resources constraints in regions is one of the challenges standing in this market.
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Organ on Chip Market Competitive Landscape
There is an intense competition in this market. Big Major companies like Emulate, TissUse GmbH, CN Nio Innovations are the leading companies in this market. They are at the forefront of developing these platforms offering drug discovery solutions, safety testing and disease modelling. Startups like Hesperos Inc., AxoSim Technologies and Nortis Inc., are delivering cutting –edge tech to develop human-on-a chip platforms for disease research and personalised medicine. Additionally, many academic institutes like Wyss Institute for Biologically Inspired Engineering at Harvard University, the Institute for Bioengineering of Catalonia and Massachusetts Institute of Technology are contributing through interdisciplinary research and innovation.
Top Player’s Company Profiles
- Emulate, Inc. (US)
- TissUse GmbH (Germany)
- CN Bio Innovations (UK)
- Hesperos, Inc. (US)
- AxoSim Technologies (US)
- Nortis, Inc. (US)
- Mimetas (Netherlands)
- MIMETAS B.V. (Netherlands)
- Tara Biosystems (US)
- Kirkstall Ltd. (UK)
- SynVivo (US)
- Cherry Biotech (France)
- InSphero AG (Switzerland)
- Elveflow (France)
- Ascendance Biotechnology, Inc. (US)
- Draper (US)
- Mimica (US)
- Zyoxel Ltd. (UK)
- AxoNet Medical Systems, Inc. (US)
- AxoSim Technologies (US)
Recent Developments
- In June 2023, MatTek Life Sciences announced a strategic partnership with AIM Biotech enabling the availability of AIM Biotech portfolio for sale through MatTek.
- In June 2023, Dynamic42 raised an undisclosed amount through a Series A funding round to expand internationally.
- In June 2023, Emulate launched Emulate Chip-A1 to widen its applications in cancer and cosmetic markets.
Organ on Chip Key Market Trends
- Focus on accurate drug predictions: Due to the rising costs and decreasing effectiveness of research and development of drugs, the pharmaceutical industry faces many difficulties. Therefore, the companies are testing new methods produce accurate drug safety and effectiveness predictions.
- Advancements in stem cell engineering: Improvements in stem cell engineering could be incorporated into organ on chip technology to create personalized models to forecast the toxicity and efficacy of a drug for a particular patient. This could result in more effective human trials with significantly less preclinical testing needed.
Organ on Chip Market SkyQuest Analysis
SkyQuest’s ABIRAW (Advanced Business Intelligence, Research & Analysis Wing) is our Business Information Services team that Collects, Collates, Co-relates, and Analyses the Data collected by means of Primary Exploratory Research backed by robust Secondary Desk research.
According to our Global Organ on Chip Market analysis, the market shows a huge growth in upcoming years. With the evolution in technologies, AI and development in technological infrastructure, the innovations in this field are very significant. Companies with the help of different research and academic institutes are catering towards the demand for better healthcare solutions. Although, ethical considerations and societal implications along with high manufacturing costs can create a challenge in this market. High costs associated with equipment, materials and specialized expertise are some of the barriers that this market need to overcome. At the same time, the market raises concern regarding responsible and sustainable development of the organ-on-chip technology.
| Report Metric | Details |
|---|---|
| Market size value in 2022 | USD 52.53 Billion |
| Market size value in 2031 | USD 448.92 Billion |
| Growth Rate | 30.76% |
| Base year | 2023 |
| Forecast period | 2024-2031 |
| Forecast Unit (Value) | USD Billion |
| Segments covered |
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| Regions covered | North America (US, Canada), Europe (Germany, France, United Kingdom, Italy, Spain, Rest of Europe), Asia Pacific (China, India, Japan, Rest of Asia-Pacific), Latin America (Brazil, Rest of Latin America), Middle East & Africa (South Africa, GCC Countries, Rest of MEA) |
| Companies covered |
|
| Customization scope | Free report customization with purchase. Customization includes:-
|
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Table Of Content
Executive Summary
Market overview
- Exhibit: Executive Summary – Chart on Market Overview
- Exhibit: Executive Summary – Data Table on Market Overview
- Exhibit: Executive Summary – Chart on Organ on Chip Market Characteristics
- Exhibit: Executive Summary – Chart on Market by Geography
- Exhibit: Executive Summary – Chart on Market Segmentation
- Exhibit: Executive Summary – Chart on Incremental Growth
- Exhibit: Executive Summary – Data Table on Incremental Growth
- Exhibit: Executive Summary – Chart on Vendor Market Positioning
Parent Market Analysis
Market overview
Market size
- Market Dynamics
- Exhibit: Impact analysis of DROC, 2021
- Drivers
- Opportunities
- Restraints
- Challenges
- Exhibit: Impact analysis of DROC, 2021
- SWOT Analysis
KEY MARKET INSIGHTS
- Technology Analysis
- (Exhibit: Data Table: Name of technology and details)
- Pricing Analysis
- (Exhibit: Data Table: Name of technology and pricing details)
- Supply Chain Analysis
- (Exhibit: Detailed Supply Chain Presentation)
- Value Chain Analysis
- (Exhibit: Detailed Value Chain Presentation)
- Ecosystem Of the Market
- Exhibit: Parent Market Ecosystem Market Analysis
- Exhibit: Market Characteristics of Parent Market
- IP Analysis
- (Exhibit: Data Table: Name of product/technology, patents filed, inventor/company name, acquiring firm)
- Trade Analysis
- (Exhibit: Data Table: Import and Export data details)
- Startup Analysis
- (Exhibit: Data Table: Emerging startups details)
- Raw Material Analysis
- (Exhibit: Data Table: Mapping of key raw materials)
- Innovation Matrix
- (Exhibit: Positioning Matrix: Mapping of new and existing technologies)
- Pipeline product Analysis
- (Exhibit: Data Table: Name of companies and pipeline products, regional mapping)
- Macroeconomic Indicators
COVID IMPACT
- Introduction
- Impact On Economy—scenario Assessment
- Exhibit: Data on GDP - Year-over-year growth 2016-2022 (%)
- Revised Market Size
- Exhibit: Data Table on Organ on Chip Market size and forecast 2021-2027 ($ million)
- Impact Of COVID On Key Segments
- Exhibit: Data Table on Segment Market size and forecast 2021-2027 ($ million)
- COVID Strategies By Company
- Exhibit: Analysis on key strategies adopted by companies
MARKET DYNAMICS & OUTLOOK
- Market Dynamics
- Exhibit: Impact analysis of DROC, 2021
- Drivers
- Opportunities
- Restraints
- Challenges
- Exhibit: Impact analysis of DROC, 2021
- Regulatory Landscape
- Exhibit: Data Table on regulation from different region
- SWOT Analysis
- Porters Analysis
- Competitive rivalry
- Exhibit: Competitive rivalry Impact of key factors, 2021
- Threat of substitute products
- Exhibit: Threat of Substitute Products Impact of key factors, 2021
- Bargaining power of buyers
- Exhibit: buyers bargaining power Impact of key factors, 2021
- Threat of new entrants
- Exhibit: Threat of new entrants Impact of key factors, 2021
- Bargaining power of suppliers
- Exhibit: Threat of suppliers bargaining power Impact of key factors, 2021
- Competitive rivalry
- Skyquest special insights on future disruptions
- Political Impact
- Economic impact
- Social Impact
- Technical Impact
- Environmental Impact
- Legal Impact
Market Size by Region
- Chart on Market share by geography 2021-2027 (%)
- Data Table on Market share by geography 2021-2027(%)
- North America
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- USA
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Canada
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Europe
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- Germany
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Spain
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- France
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- UK
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of Europe
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Asia Pacific
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- China
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- India
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Japan
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- South Korea
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of Asia Pacific
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Latin America
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- Brazil
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of South America
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Middle East & Africa (MEA)
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- GCC Countries
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- South Africa
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of MEA
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
KEY COMPANY PROFILES
- Competitive Landscape
- Total number of companies covered
- Exhibit: companies covered in the report, 2021
- Top companies market positioning
- Exhibit: company positioning matrix, 2021
- Top companies market Share
- Exhibit: Pie chart analysis on company market share, 2021(%)
- Total number of companies covered
Methodology
For the Organ on Chip Market, our research methodology involved a mixture of primary and secondary data sources. Key steps involved in the research process are listed below:
1. Information Procurement: This stage involved the procurement of Market data or related information via primary and secondary sources. The various secondary sources used included various company websites, annual reports, trade databases, and paid databases such as Hoover's, Bloomberg Business, Factiva, and Avention. Our team did 45 primary interactions Globally which included several stakeholders such as manufacturers, customers, key opinion leaders, etc. Overall, information procurement was one of the most extensive stages in our research process.
2. Information Analysis: This step involved triangulation of data through bottom-up and top-down approaches to estimate and validate the total size and future estimate of the Organ on Chip Market.
3. Report Formulation: The final step entailed the placement of data points in appropriate Market spaces in an attempt to deduce viable conclusions.
4. Validation & Publishing: Validation is the most important step in the process. Validation & re-validation via an intricately designed process helped us finalize data points to be used for final calculations. The final Market estimates and forecasts were then aligned and sent to our panel of industry experts for validation of data. Once the validation was done the report was sent to our Quality Assurance team to ensure adherence to style guides, consistency & design.
Analyst Support
Customization Options
With the given market data, our dedicated team of analysts can offer you the following customization options are available for the Organ on Chip Market:
Product Analysis: Product matrix, which offers a detailed comparison of the product portfolio of companies.
Regional Analysis: Further analysis of the Organ on Chip Market for additional countries.
Competitive Analysis: Detailed analysis and profiling of additional Market players & comparative analysis of competitive products.
Go to Market Strategy: Find the high-growth channels to invest your marketing efforts and increase your customer base.
Innovation Mapping: Identify racial solutions and innovation, connected to deep ecosystems of innovators, start-ups, academics, and strategic partners.
Category Intelligence: Customized intelligence that is relevant to their supply Markets will enable them to make smarter sourcing decisions and improve their category management.
Public Company Transcript Analysis: To improve the investment performance by generating new alpha and making better-informed decisions.
Social Media Listening: To analyze the conversations and trends happening not just around your brand, but around your industry as a whole, and use those insights to make better Marketing decisions.
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