USD 3.04 Billion
Protein Expression Market Size, Share, Growth Analysis, By Product and Service (Reagents, Expression Vectors), By System Type (Mammalian Cell Expression Systems, Prokaryotic Expression Systems), By Application (Therapeutic Applications, Research Applications), By End User (Pharmaceutical & Biotechnology Companies, Academic Research Institutes), By Region - Industry Forecast 2025-2032
Report ID:
SQMIG35H2291 |
Region:
Global |
Published Date: November, 2024
Pages:
209
|Tables:
116
|Figures:
73
Protein Expression Market Insights
Protein Expression Market size was valued at USD 3.29 Billion in 2023 and is poised to grow from USD 3.73 Billion in 2024 to USD 10.11 Billion by 2032, growing at a CAGR of 13.3% during the forecast period (2025-2032).
In recent times, the demand for protein expression market is increasing due to the high requirement for recombinant proteins in therapeutic uses. Innovation in biotechnology is improving efficiency and increasing protein production. Moreover, the emergence of personalized medicine has also developed a requirement for customized protein-based therapies. The growth of the protein expression market is rapidly increasing owing to the popularity of personalized therapeutics and the constant research & development activities that contribute to the advancement of protein expression. The identification of protein therapeutics is boosted through protein engineering along with the artificial production of recombinant proteins. Furthermore, the development in technology is creating immense opportunities for improving patient care with the help of personalized medical therapies. The demand for protein therapeutics market is rapidly increasing due to protein engineering and the synthetic development of recombinant proteins. Market players are also engaging in strategic partnerships with academic facilities for developing innovative technologies that will support personalized medical treatment, resulting in the progression of the market. Many businesses are also funding research for protein expression technologies such as baculovirus expression systems, transient expression, and steady expression. These technologies can be used insect cells and mammalian cells, further expanding the development of protein expression market.
Market snapshot - 2024-2031
Global Market Size
Largest Segment
Reagents
Fastest Growth
Therapeutic
Growth Rate
10.22% CAGR
Global Protein Expression Market ($ Bn)
Country Share for North America Region (%)
To get more reports on the above market click here to Buy The Report
Protein Expression Market Segmental Analysis
Global Protein Expression Market is segmented on the product & service, system type, application, end user, and region. By product and service, the market is segmented into Reagents, Expression Vectors, Competent Cells, Instruments, and Services. By system type, the market is segmented into Mammalian Cell Expression Systems, Prokaryotic Expression Systems, Insect Cell Expression Systems, Yeast Expression Systems, Cell-Free Expression Systems, and Algal-Based Expression Systems. By application, the market is segmented into Therapeutic Applications, Research Applications, and Industrial Applications. By end user, the market is segmented into Pharmaceutical & Biotechnology Companies, Academic Research Institutes, Contract Research Organizations & Contract Development and Manufacturing Organizations (CROs & CDMOs), and Other End Users. By region, the market is segmented into North America, Europe, Asia Pacific, Middle East and Africa, and Latin America.
Analysis by Expression System
Based on expression system, the market is divided into prokaryotic and mammalian cells. The prokaryotic segment is leading the market with the largest market share. There is high demand for prokaryotic in the market because it is easy to manage and fulfils most of the purposes in research. It has many favorable features like it can produce massive scale of recombinant protein in a short span of time and at minimized expenses. These characteristics are also increasing the demand for prokaryotic. Furthermore, there has also been advancement in prokaryotic synthetic biology by incorporating eukaryotic transcription factors, particularly the QF factor into E. coli. This development has enabled to improve gene expression control and the development of genetic circuits that can maintain robust output signals even during low input levels.
The mammalian cell segment is witnessing the fastest growth in the protein expression market. This is mainly because several pharmaceutical firms are using mammalian expression systems for developing and creating protein transiently or completely formed cell lines. This happens when the specific expression constructs mix into the genome host. Several pharmaceutical organizations are also utilizing temporary or permanent cell lines as mammalian expression platforms for producing proteins. However, the utilization of the system depends on the goal and tactic. The prokaryotic can be considered ideal for antigen synthesis, structural studies, and activity studies where post-translational is not necessary. But companies prefer mammalian cells for developing proteins, medicines, and immunizations.
Analysis by Application
Based on application, the market is segmented into therapeutic, industrial, and research. The therapeutic segment is leading the market with maximum market share. The growth of this segment is increasing rapidly because they can be easily customized for the target, making them more efficient and with reduced chances of side effects. Furthermore, it can also be represented as a substitute treatment during lack of functional protein in the body because of gene deficiency. The demand for this segment is increasing rapidly because of the rising participation of organizations in advancing protein-based therapeutics. Furthermore, a possible tactic for minimizing manufacturing expenses consists of using Escherichia coli. This can be utilized for the production of biomolecules like full-length antibodies, which are generally manufacturing using Chinese Hamster Ovary (CHO) cells. This method is supported by the rising adoption of constant manufacturing procedures and the shift towards cell-free synthesis methods.
The industrial segment is witnessing the fastest growth in the protein expression market. The growth of this segment is mainly boosted by the rising demand for high-quality protein in several applications like food & feed additives, enzymes for industrial procedures, and biofuels. The emergence of biomanufacturing methods is increasing efficiency and cost-effectiveness. This is making it more appealing for industries who are trying to use sustainable production processes. In June 2024, researchers at the Indian Institute of Science’s Department of Biochemistry launched an innovative method for developing recombinant proteins. Conventionally this procedure depended on methanol in yeast cell factories, which creates safety risks and can result in hazardous products. But this new procedure uses monosodium glutamate (MSG), a popular food additive, providing a safe substitute for mass production.
To get detailed analysis on other segments, Request For Free Sample Report
Protein Expression Market Regional Insights
Based on region, North America is dominating the protein expression market with the largest market share. This region is growing immensely due to the presence of major players combined with increasing funds for research & development with robust lines of biosimilar. Furthermore, the companies in this region are also engaging in collaboration with academic facilities. This has become one of the major drivers of the growth of the market as it is helping them to introduce new innovative products to the market. Moreover, the rising demand for therapeutic proteins and monoclonal antibodies is also increasing due to the advancements in biotechnology. The popularity of personalized medicine and the increasing prevalence of chronic diseases are also propelling the growth of the market in this region. These factors are increasing the demand for protein expression market in North America.
Europe is experiencing the fastest growth in the protein expression market. This growth in this region is mainly due to collaborative research initiatives among the market leaders and academic facilities. Nations like Germany, France, and UK are leading the innovation because of their robust regulatory structures that support the advancement of biopharmaceutical. The growing emphasis on biologics for treating various diseases is also increasing investment in engineering technologies. Furthermore, Europe is extremely dedicated towards sustainability, which is boosting interest in plant-based protein expression systems as a substitute to conventional processes. These factors are augmenting the growth of protein expression market and increasing advancements in Europe.
Global Protein Expression Market By Geography
- Largest
- Fastest
To know more about the market opportunities by region and country, click here to
Buy The Complete Report
Protein Expression Market Dynamics
Drivers
Increasing Utilization of E. Coli Bacteria
- The protein expression market is expanding rapidly owing to the massive scale manufacturing of protein by utilizing E. coli bacteria. This bacteria is the most frequently utilized artificial expression host and is massively used due to their genomic and sequencing system. It is responsible for smoothing the cloning processes and making E. coli host the most preferred choice in pharmaceutical sector. Moreover, this procedure also increases the strength of binding in promoter region 7 and helps in transcription.
Growing Prevalence of Chronic Diseases
- The primary factor that is boosting the growth of the market is the increasing incidences of several chronic illnesses such as arthritis, cancer, diabetes, asthma, and infectious disorders. This is increasing the demand for advanced biologics such as therapeutic protein as it helps in curing chronic diseases like these. The manufacturers are utilizing these products extensively for the advancement and production of biologics. This growing demand for biologics for treating chronic diseases is fueling the adoption of protein expression products.
Restraints
High Expense of Protein Expression
- There are immense restrictions for the new organizations to enter the market and the high expense of protein expression reagents is hindering the growth of the market. Furthermore, very little awareness of diseases and the high expense of products is preventing many companies from venturing into the market. This is especially true for the developing nations and for small companies who have limited budgets. The lack of favorable insurance systems is also restricting the adoption of eukaryotic expression system products in the emerging economies.
Stringent Government Rules
- Many countries have implemented stringent government rules for the development and production of biologics. It can restrict the growth and development of the market. Moreover, before regulatory approvals, the latest biologics also has to go through intense clinical and preclinical trials. The commercialization of biologics, like hormones, insulin, therapeutic antibodies, vaccines, depends on the successfully completing the clinical trials.
Request Free Customization of this report to help us to meet your business objectives.
Protein Expression Market Competitive Landscape
The protein expression market is extremely dynamic with immense competition among the market players and startups. The market leaders are constantly investing in research and development to maintain their market share. Companies are also engaging in collaborations and partnerships for increasing innovation and product diversity. This unique market setting helps in the growth of technological innovation resulting in the advent of novel protein systems and solutions.
Top Player’s Company Profile
- Thermo Fisher Scientific, Inc. (US)
- Merck KGaA (Germany)
- Genscript Biotech Corporation (China)
- Agilent Technologies Inc. (US)
- Takara Bio, Inc. (Japan)
- Bio-Rad Laboratories, Inc. (US)
- Qiagen N.V. (Netherlands)
- Charles River Laboratories International, Inc. (US)
- Danaher Corporation (US)
- Sartorius AG (Germany)
- Corning Incorporated (US)
- Fujifilm Irvine Scientific, Inc. (US)
- Lonza Group AG (Switzerland)
- Bioneer Corporation (South Korea)
- Promega Corporation (US)
- Oxford Expression Technologies Ltd. (UK)
- Proteogenix (France)
- Abeomics Inc. (US)
- New England Biolabs, Inc. (US)
- Promab Biotechnologies (US)
- Sino Biological, Inc. (China)
- Jena Bioscience (Germany)
- Lifesensors, Inc. (US)
- Leading Biology, Inc. (US)
- Peak Proteins (UK)
Recent Developments
- In 2022, Beijing Luzhu Biotechnology and Maxvax Biotechnology collaborated to increase fund for their vaccine R&D projects. They secured almost USD 74 million in series B funding that can finance many clinical trials.
- In February 2022, Thermo Fisher Scientific introduced its bioprocessing manufacturing facility in Pennsylvania. The facility has the potential to manufacture essential components for creating new biologics.
- In April 2024, Expression Systems collaborated with Thomson. The goal was to highlight the efficiency of their ESF AdvanCD cell culture medium combined with Thomson’s Optimum Growth flasks.
Protein Expression Key Market Trends
- Advent of Microfluidics: The emergence of microfluidics technology for protein expression is propelling the growth of the market. It can manipulate fluids in microscale devices and enable accurate control over less amount of fluids. This technology is perfect for protein expression. Microfluidic devices can develop small channels and chambers that offer a setting for protein expression. It allows quick and effective screening of various conditions.
- Increasing Interest in Protein Biologics: Biologics are utilized for addressing most of the chronic diseases, like cancer, autoimmune illness, and other serious diseases. Biologics consists of vaccines, blood & blood components, and modified medicinal proteins. Unique antibodies, pegylated proteins, hormones, and enzymes create the other 14 types of biologics, and all of them are necessary protein translation. The increasing demand for products and services related to protein translation is expanding the market.
Protein Expression Market SkyQuest Analysis
SkyQuest’s ABIRAW (Advanced Business Intelligence, Research & Analysis Wing) is our Business Information Services team that Collects, Collates, Correlates, and Analyses the Data collected by means of Primary Exploratory Research backed by robust Secondary Desk research.
As per SkyQuest analysis, the global protein expression market to grow at a rapid speed due to the adaptability nature of protein expression. They offer a more efficient method of therapy and have less chances of negative impact. Furthermore, it can also serve as a replacement therapy when any defective gene restricts the body from developing efficient proteins. The market leaders are also emphasizing sustainability and eco-friendly practices that are restructuring the competitive nature of the market. This is because regulatory bodies and consumers are demanding responsible manufacturing of proteins. The goal of efficiency in biopharmaceuticals, personalized medicine, and more is boosting the competition and increasing growth of the market.
| Report Metric | Details |
|---|---|
| Market size value in 2022 | USD 2.90 billion |
| Market size value in 2031 | USD 8.92 billion |
| Growth Rate | 13.3% |
| Base year | 2023 |
| Forecast period | 2024-2031 |
| Forecast Unit (Value) | USD Billion |
| Segments covered |
|
| Regions covered | North America (US, Canada), Europe (Germany, France, United Kingdom, Italy, Spain, Rest of Europe), Asia Pacific (China, India, Japan, Rest of Asia-Pacific), Latin America (Brazil, Rest of Latin America), Middle East & Africa (South Africa, GCC Countries, Rest of MEA) |
| Companies covered |
|
| Customization scope | Free report customization with purchase. Customization includes:-
|
To get a free trial access to our platform which is a one stop solution for all your data requirements for quicker decision making. This platform allows you to compare markets, competitors who are prominent in the market, and mega trends that are influencing the dynamics in the market. Also, get access to detailed SkyQuest exclusive matrix.
Buy The Complete Report to read the analyzed strategies adopted by the top vendors either to retain or gain market share
Table Of Content
Executive Summary
Market overview
- Exhibit: Executive Summary – Chart on Market Overview
- Exhibit: Executive Summary – Data Table on Market Overview
- Exhibit: Executive Summary – Chart on Protein Expression Market Characteristics
- Exhibit: Executive Summary – Chart on Market by Geography
- Exhibit: Executive Summary – Chart on Market Segmentation
- Exhibit: Executive Summary – Chart on Incremental Growth
- Exhibit: Executive Summary – Data Table on Incremental Growth
- Exhibit: Executive Summary – Chart on Vendor Market Positioning
Parent Market Analysis
Market overview
Market size
- Market Dynamics
- Exhibit: Impact analysis of DROC, 2021
- Drivers
- Opportunities
- Restraints
- Challenges
- Exhibit: Impact analysis of DROC, 2021
- SWOT Analysis
KEY MARKET INSIGHTS
- Technology Analysis
- (Exhibit: Data Table: Name of technology and details)
- Pricing Analysis
- (Exhibit: Data Table: Name of technology and pricing details)
- Supply Chain Analysis
- (Exhibit: Detailed Supply Chain Presentation)
- Value Chain Analysis
- (Exhibit: Detailed Value Chain Presentation)
- Ecosystem Of the Market
- Exhibit: Parent Market Ecosystem Market Analysis
- Exhibit: Market Characteristics of Parent Market
- IP Analysis
- (Exhibit: Data Table: Name of product/technology, patents filed, inventor/company name, acquiring firm)
- Trade Analysis
- (Exhibit: Data Table: Import and Export data details)
- Startup Analysis
- (Exhibit: Data Table: Emerging startups details)
- Raw Material Analysis
- (Exhibit: Data Table: Mapping of key raw materials)
- Innovation Matrix
- (Exhibit: Positioning Matrix: Mapping of new and existing technologies)
- Pipeline product Analysis
- (Exhibit: Data Table: Name of companies and pipeline products, regional mapping)
- Macroeconomic Indicators
COVID IMPACT
- Introduction
- Impact On Economy—scenario Assessment
- Exhibit: Data on GDP - Year-over-year growth 2016-2022 (%)
- Revised Market Size
- Exhibit: Data Table on Protein Expression Market size and forecast 2021-2027 ($ million)
- Impact Of COVID On Key Segments
- Exhibit: Data Table on Segment Market size and forecast 2021-2027 ($ million)
- COVID Strategies By Company
- Exhibit: Analysis on key strategies adopted by companies
MARKET DYNAMICS & OUTLOOK
- Market Dynamics
- Exhibit: Impact analysis of DROC, 2021
- Drivers
- Opportunities
- Restraints
- Challenges
- Exhibit: Impact analysis of DROC, 2021
- Regulatory Landscape
- Exhibit: Data Table on regulation from different region
- SWOT Analysis
- Porters Analysis
- Competitive rivalry
- Exhibit: Competitive rivalry Impact of key factors, 2021
- Threat of substitute products
- Exhibit: Threat of Substitute Products Impact of key factors, 2021
- Bargaining power of buyers
- Exhibit: buyers bargaining power Impact of key factors, 2021
- Threat of new entrants
- Exhibit: Threat of new entrants Impact of key factors, 2021
- Bargaining power of suppliers
- Exhibit: Threat of suppliers bargaining power Impact of key factors, 2021
- Competitive rivalry
- Skyquest special insights on future disruptions
- Political Impact
- Economic impact
- Social Impact
- Technical Impact
- Environmental Impact
- Legal Impact
Market Size by Region
- Chart on Market share by geography 2021-2027 (%)
- Data Table on Market share by geography 2021-2027(%)
- North America
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- USA
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Canada
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Europe
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- Germany
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Spain
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- France
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- UK
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of Europe
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Asia Pacific
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- China
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- India
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Japan
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- South Korea
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of Asia Pacific
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Latin America
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- Brazil
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of South America
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Middle East & Africa (MEA)
- Chart on Market share by country 2021-2027 (%)
- Data Table on Market share by country 2021-2027(%)
- GCC Countries
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- South Africa
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
- Rest of MEA
- Exhibit: Chart on Market share 2021-2027 (%)
- Exhibit: Market size and forecast 2021-2027 ($ million)
KEY COMPANY PROFILES
- Competitive Landscape
- Total number of companies covered
- Exhibit: companies covered in the report, 2021
- Top companies market positioning
- Exhibit: company positioning matrix, 2021
- Top companies market Share
- Exhibit: Pie chart analysis on company market share, 2021(%)
- Total number of companies covered
Methodology
For the Protein Expression Market, our research methodology involved a mixture of primary and secondary data sources. Key steps involved in the research process are listed below:
1. Information Procurement: This stage involved the procurement of Market data or related information via primary and secondary sources. The various secondary sources used included various company websites, annual reports, trade databases, and paid databases such as Hoover's, Bloomberg Business, Factiva, and Avention. Our team did 45 primary interactions Globally which included several stakeholders such as manufacturers, customers, key opinion leaders, etc. Overall, information procurement was one of the most extensive stages in our research process.
2. Information Analysis: This step involved triangulation of data through bottom-up and top-down approaches to estimate and validate the total size and future estimate of the Protein Expression Market.
3. Report Formulation: The final step entailed the placement of data points in appropriate Market spaces in an attempt to deduce viable conclusions.
4. Validation & Publishing: Validation is the most important step in the process. Validation & re-validation via an intricately designed process helped us finalize data points to be used for final calculations. The final Market estimates and forecasts were then aligned and sent to our panel of industry experts for validation of data. Once the validation was done the report was sent to our Quality Assurance team to ensure adherence to style guides, consistency & design.
Analyst Support
Customization Options
With the given market data, our dedicated team of analysts can offer you the following customization options are available for the Protein Expression Market:
Product Analysis: Product matrix, which offers a detailed comparison of the product portfolio of companies.
Regional Analysis: Further analysis of the Protein Expression Market for additional countries.
Competitive Analysis: Detailed analysis and profiling of additional Market players & comparative analysis of competitive products.
Go to Market Strategy: Find the high-growth channels to invest your marketing efforts and increase your customer base.
Innovation Mapping: Identify racial solutions and innovation, connected to deep ecosystems of innovators, start-ups, academics, and strategic partners.
Category Intelligence: Customized intelligence that is relevant to their supply Markets will enable them to make smarter sourcing decisions and improve their category management.
Public Company Transcript Analysis: To improve the investment performance by generating new alpha and making better-informed decisions.
Social Media Listening: To analyze the conversations and trends happening not just around your brand, but around your industry as a whole, and use those insights to make better Marketing decisions.
USA (+1) 351-333-4748
