USD 103.31 million
Report ID:
SQMIG35I2121 |
Region:
Global |
Published Date: February, 2024
Pages:
157
|Tables:
88
|Figures:
81
Proteolysis-targeting Chimeric Molecules (PROTACs) Market size was valued at USD 113.85 million in 2022 and is poised to grow from USD 125.46 million in 2023 to USD 272.88 million by 2031, growing at a CAGR of 10.20% in the forecast period (2024-2031).
PROTACs are designed to have high selectivity and specificity for their target proteins, which allows them to degrade proteins that are difficult to target using traditional small molecule inhibitors. In addition, because PROTACs induce protein degradation rather than simply inhibiting protein function, they can potentially achieve more complete and durable inhibition of target proteins.
The development of PROTACs has been driven by the need to target “undruggable” proteins, which are proteins that cannot be effectively targeted using traditional small molecule inhibitors. These undruggable proteins often lack well-defined binding pockets that can be targeted by small molecules, or they may be present in intracellular locations that are difficult for small molecules to access. By inducing protein degradation, PROTACs can effectively target these undruggable proteins by using ligands that bind to specific domains on the protein surface rather than binding to a specific binding pocket. PROTACs have been shown to be effective against a variety of protein targets, including transcription factors, kinases, and signaling proteins. One of the key advantages of PROTACs is their ability to induce protein degradation in a highly selective manner. This selectivity is achieved through the use of ligands that bind specifically to the target protein and the E3 ubiquitin ligase, which ensures that only the target protein is degraded and not other proteins in the cell.
PROTACs have also been shown to be effective in preclinical models of cancer. For example, one study demonstrated that a PROTAC targeting the androgen receptor was able to induce degradation of the receptor and inhibit the growth of prostate cancer cells in vitro and in vivo. Another study showed that a PROTAC targeting BCL-2, a protein that is overexpressed in many types of cancer, was able to induce apoptosis (programmed cell death) in cancer cells. Despite their potential as a new class of therapeutics, there are still several challenges that must be addressed in the development of PROTACs. One challenge is the design of ligands that are able to bind specifically to the target protein and the E3 ubiquitin ligase. Another challenge is the optimization of the pharmacokinetic and pharmacodynamic properties of PROTACs to ensure that they are effective and well-tolerated in vivo.
US Proteolysis-targeting chimeric molecules (PROTACs) Market is poised to grow at a sustainable CAGR for the next forecast year.
Global Market Size
USD 103.31 million
Largest Segment
Cancer
Fastest Growth
Cancer
Growth Rate
10.2% CAGR
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Global Proteolysis-targeting chimeric molecules (PROTACs) market is segmented by indication, technology, and end-user. Based on indication, the market can be segmented into cancer, autoimmune diseases, and neurodegenerative disorders. Based on technology, the market can be segmented into bifunctional and monovalent. Based on end-user, the market can be segmented into pharmaceutical companies, academic and research institutions, and contract research organizations (CROs). Based on region, the market is segmented into North America, Europe, Asia Pacific, Middle East and Africa, and Latin America.
Proteolysis-targeting Chimeric Molecules (PROTACs) Market Analysis by Indication
By type, the market can be segmented into cancer, autoimmune diseases, and neurodegenerative disorders. The cancer segment dominated the global market. Cancer is one of the most significant indications for PROTACs, with many of the drugs in development focused on this area. There are several reasons for this. First, cancer is a significant global health issue, with millions of people diagnosed with the disease each year. Second, cancer is a complex and diverse disease, with many different types and subtypes that require specific treatments. Finally, cancer is often difficult to treat using traditional chemotherapy and radiation therapy, making the need for new treatments especially pressing.
Within the cancer segment, different types of cancer are further segmented based on the specific protein targets. For example, some PROTACs are designed to target and degrade the androgen receptor in prostate cancer, while others target estrogen receptor in breast cancer.
Autoimmune diseases is the fastest growing segment. It represent another area of significant medical need, and PROTACs have the potential to be used to treat a variety of conditions in this segment. Autoimmune diseases occur when the immune system attacks healthy cells and tissues in the body, leading to chronic inflammation and tissue damage. Lupus, multiple sclerosis, and rheumatoid arthritis are a few examples of autoimmune disorders.
In autoimmune disease, PROTACs are designed to target and degrade proteins that play a key role in the immune response. For example, some PROTACs are designed to degrade Bruton's tyrosine kinase (BTK), a protein that is essential for B-cell receptor signaling and is implicated in the pathogenesis of many autoimmune diseases.
Proteolysis-targeting Chimeric Molecules (PROTACs) Market Analysis by Technology
By technology, the market can be segmented into bifunctional and monovalent. Bifunctional segment dominated the global market. Bifunctional PROTACs have two ligands that bind to both the target protein and the E3 ubiquitin ligase, allowing for the recruitment of the ligase to the target protein. The two ligands are connected by a linker, which determines the distance between the target protein and the E3 ligase. Bifunctional PROTACs are generally more common in the market, and they can be designed to target a wide range of proteins.
On the other hand, monovalent segment is expected to grow at the fastest CAGR. Monovalent PROTACs have only one ligand that binds to both the target protein and the E3 ubiquitin ligase. This approach is believed to offer greater specificity and less toxicity compared to bifunctional PROTACs. However, the design of monovalent PROTACs is challenging due to the need to achieve a specific orientation of the ligands relative to the target protein and the E3 ligase.
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North America is one of the largest markets for PROTACs, with the United States being the dominant country in the region. The market is expected to grow significantly due to the increasing number of biotechnology and pharmaceutical companies in the region and the growing interest in targeted therapies for cancer and other diseases. The dominant players in the North American PROTACs market include Arvinas, C4 Therapeutics, Nurix, and Kymera Therapeutics. These companies are focused on developing PROTACs for a wide range of indications, including cancer, inflammatory diseases, and neurodegenerative diseases. Arvinas, in particular, has been successful in advancing its lead PROTAC candidate, ARV-110, for the treatment of prostate cancer, and has entered into a partnership with Pfizer for the development of additional PROTAC candidates. The North American PROTACs market is also characterized by a large number of academic and research institutions that are focused on developing new PROTACs and advancing the understanding of protein degradation as a therapeutic modality. For example, the University of Michigan has developed a novel class of PROTACs that target the androgen receptor for the treatment of prostate cancer, while the University of California, San Francisco is focused on developing PROTACs for the treatment of HIV.
On the other hand, the Asia-Pacific (APAC) region is one of the fastest-growing regions in the Proteolysis-targeting chimeric molecules (PROTACs) market. Countries such as China, Japan, and India are witnessing rapid growth in their pharmaceutical sectors, driven by rising income levels, an aging population, and increasing healthcare spending. The region is also home to a large pool of talented researchers and scientists who are contributing to the development of new drugs, including PROTACs. China, in particular, is expected to become a major player in the global PROTACs market. The country has made significant investments in its biopharmaceutical industry, with a focus on developing innovative drugs to address the country's healthcare needs. The Chinese government has also implemented policies to encourage domestic research and development, which is driving the growth of the PROTACs market in the country. Cancer treatment is emerging as a key area of focus. The disease is a major public health concern in both North America and APAC, with high mortality rates and significant economic burden. PROTACs have the potential to revolutionize cancer treatment by targeting specific proteins that are critical for cancer cell survival, leading to their degradation. This approach is expected to be more effective and less toxic than traditional chemotherapy and radiation therapy.
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Proteolysis-targeting Chimeric Molecules (PROTACs) Market Drivers
Increasing target specificity in drug design
Novel Mechanism of Action
Proteolysis-targeting Chimeric Molecules (PROTACs) Market Restraints
Effective and safe designing or synthesizing of molecule
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Global Proteolysis-targeting chimeric molecules (PROTACs) market is characterized by several companies operating in the market, with different levels of market share and specialization. Competition of PROTACs is currently limited, with a few key players dominating the market. Arvinas, a biotech company, has emerged as a leader in the development of PROTACs, with several candidates in preclinical and clinical stages of development. Other companies, such as C4 Therapeutics and Kymera Therapeutics, have also entered the PROTACs space, with multiple candidates in various stages of development. Despite the limited competition, the potential for PROTACs to address previously undruggable targets has garnered significant attention from pharmaceutical companies, leading to numerous partnerships and collaborations in the field. Additionally, the development of PROTACs has spurred interest in related technologies, such as molecular glues and protein degraders, further expanding the competitive landscape of this emerging field.
Proteolysis-targeting Chimeric Molecules (PROTACs) Market Top Player’s Company Profiles
Proteolysis-targeting Chimeric Molecules (PROTACs) Market Recent Developments
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According to our global Proteolysis-targeting chimeric molecules (PROTACs) market analysis, the market is rapidly evolving and holds tremendous potential in revolutionizing drug development for previously undruggable targets. The success of early clinical trials and partnerships with major pharmaceutical companies demonstrate the promising outlook for PROTACs in the coming years. However, the development of effective and safe PROTACs remains a significant challenge, with the delicate balance between target binding and E3 ligase recruitment requiring careful consideration. The competitive landscape of the PROTACs market is currently limited, with a few key players dominating the space. However, the increasing interest in PROTACs technology has led to the entry of new companies and collaborations, expanding the competitive landscape. As the field of PROTACs continues to advance, the potential applications for this technology in various disease areas are vast, including oncology, neurodegenerative diseases, and genetic disorders. The ongoing clinical trials and preclinical development of PROTACs suggest that this technology could become a new class of drugs with significant benefits for patients, such as reduced drug resistance and fewer side effects.
Report Metric | Details |
---|---|
Market size value in 2022 | USD 113.85 million |
Market size value in 2031 | USD 272.88 million |
Growth Rate | 10.20% |
Base year | 2023 |
Forecast period | 2024-2031 |
Forecast Unit (Value) | USD Million |
Segments covered |
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Regions covered | North America (US, Canada), Europe (Germany, France, United Kingdom, Italy, Spain, Rest of Europe), Asia Pacific (China, India, Japan, Rest of Asia-Pacific), Latin America (Brazil, Rest of Latin America), Middle East & Africa (South Africa, GCC Countries, Rest of MEA) |
Companies covered |
Proteolysis-targeting Chimeric Molecules (PROTACs) Market Recent Developments
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For the Proteolysis-targeting chimeric molecules (PROTACs) Market, our research methodology involved a mixture of primary and secondary data sources. Key steps involved in the research process are listed below:
1. Information Procurement: This stage involved the procurement of Market data or related information via primary and secondary sources. The various secondary sources used included various company websites, annual reports, trade databases, and paid databases such as Hoover's, Bloomberg Business, Factiva, and Avention. Our team did 45 primary interactions Globally which included several stakeholders such as manufacturers, customers, key opinion leaders, etc. Overall, information procurement was one of the most extensive stages in our research process.
2. Information Analysis: This step involved triangulation of data through bottom-up and top-down approaches to estimate and validate the total size and future estimate of the Proteolysis-targeting chimeric molecules (PROTACs) Market.
3. Report Formulation: The final step entailed the placement of data points in appropriate Market spaces in an attempt to deduce viable conclusions.
4. Validation & Publishing: Validation is the most important step in the process. Validation & re-validation via an intricately designed process helped us finalize data points to be used for final calculations. The final Market estimates and forecasts were then aligned and sent to our panel of industry experts for validation of data. Once the validation was done the report was sent to our Quality Assurance team to ensure adherence to style guides, consistency & design.
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Report ID: SQMIG35I2121