Global Proteolysis-targeting chimeric molecules (PROTACs) Market

Proteolysis-targeting chimeric molecules (PROTACs) Market Size, Share, Growth Analysis, By Indication(Cancer, Autoimmune Diseases, and Neurodegenerative Disorders), By Technology(Bifunctional and Monovalent), By End-User(Pharmaceutical Companies, Academic and Research Institutions, and Contract Research Organizations (Cros)), By Region - Industry Forecast 2024-2031


Report ID: SQMIG35I2121 | Region: Global | Published Date: February, 2024
Pages: 157 | Tables: 88 | Figures: 81

Proteolysis-targeting chimeric molecules (PROTACs) Market Insights

Proteolysis-targeting Chimeric Molecules (PROTACs) Market size was valued at USD 113.85 million in 2022 and is poised to grow from USD 125.46 million in 2023 to USD 272.88 million by 2031, growing at a CAGR of 10.20% in the forecast period (2024-2031).

PROTACs are designed to have high selectivity and specificity for their target proteins, which allows them to degrade proteins that are difficult to target using traditional small molecule inhibitors. In addition, because PROTACs induce protein degradation rather than simply inhibiting protein function, they can potentially achieve more complete and durable inhibition of target proteins.

The development of PROTACs has been driven by the need to target “undruggable” proteins, which are proteins that cannot be effectively targeted using traditional small molecule inhibitors. These undruggable proteins often lack well-defined binding pockets that can be targeted by small molecules, or they may be present in intracellular locations that are difficult for small molecules to access. By inducing protein degradation, PROTACs can effectively target these undruggable proteins by using ligands that bind to specific domains on the protein surface rather than binding to a specific binding pocket. PROTACs have been shown to be effective against a variety of protein targets, including transcription factors, kinases, and signaling proteins. One of the key advantages of PROTACs is their ability to induce protein degradation in a highly selective manner. This selectivity is achieved through the use of ligands that bind specifically to the target protein and the E3 ubiquitin ligase, which ensures that only the target protein is degraded and not other proteins in the cell.

PROTACs have also been shown to be effective in preclinical models of cancer. For example, one study demonstrated that a PROTAC targeting the androgen receptor was able to induce degradation of the receptor and inhibit the growth of prostate cancer cells in vitro and in vivo. Another study showed that a PROTAC targeting BCL-2, a protein that is overexpressed in many types of cancer, was able to induce apoptosis (programmed cell death) in cancer cells. Despite their potential as a new class of therapeutics, there are still several challenges that must be addressed in the development of PROTACs. One challenge is the design of ligands that are able to bind specifically to the target protein and the E3 ubiquitin ligase. Another challenge is the optimization of the pharmacokinetic and pharmacodynamic properties of PROTACs to ensure that they are effective and well-tolerated in vivo.

US Proteolysis-targeting chimeric molecules (PROTACs) Market is poised to grow at a sustainable CAGR for the next forecast year.

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Proteolysis-targeting Chimeric Molecules (PROTACs) Market size was valued at USD 113.85 million in 2022 and is poised to grow from USD 125.46 million in 2023 to USD 272.88 million by 2031, growing at a CAGR of 10.20% in the forecast period (2024-2031).

Global Proteolysis-targeting chimeric molecules (PROTACs) market is characterized by several companies operating in the market, with different levels of market share and specialization. Competition of PROTACs is currently limited, with a few key players dominating the market. Arvinas, a biotech company, has emerged as a leader in the development of PROTACs, with several candidates in preclinical and clinical stages of development. Other companies, such as C4 Therapeutics and Kymera Therapeutics, have also entered the PROTACs space, with multiple candidates in various stages of development. Despite the limited competition, the potential for PROTACs to address previously undruggable targets has garnered significant attention from pharmaceutical companies, leading to numerous partnerships and collaborations in the field. Additionally, the development of PROTACs has spurred interest in related technologies, such as molecular glues and protein degraders, further expanding the competitive landscape of this emerging field. 'AbbVie Inc.', 'Arvinas, Inc.', 'AstraZeneca plc', 'Bayer AG', 'Bristol Myers Squibb Company', 'C4 Therapeutics, Inc.', 'Cullgen Inc.', 'Daiichi Sankyo Co., Ltd.', 'GlaxoSmithKline plc', 'Gilead Sciences, Inc.', 'Kymera Therapeutics, Inc.', 'Merck & Co., Inc.', 'Nurix Therapeutics, Inc.', 'Novartis AG', 'Pfizer Inc.', 'Proteolix, Inc.', 'Progenra, Inc.', 'Sanofi S.A.', 'Takeda Pharmaceutical Company Limited', 'Zenith Epigenetics Ltd.', 'In March 2023, Aileron Therapeutics announced the initiation of a Phase 1 clinical trial of its ALRN-6924 ProTac for the treatment of advanced solid tumors. The trial will evaluate the safety and efficacy of the drug in combination with chemotherapy.', 'In February 2022, Zentalis Pharmaceuticals announced positive preliminary data from a Phase 1 clinical trial of its ZN-c3 ProTac for the treatment of solid tumors. The trial showed promising safety and efficacy data, with several patients experiencing partial responses.', 'In January 2022, Vividion Therapeutics announced a $135 million series D financing round to advance its platform for developing small-molecule protein degraders, including ProTacs. The funds will be used to advance multiple drug candidates into the clinic.', 'In December 2021, Kymera Therapeutics announced positive preclinical data for its lead ProTac candidate, KYM-001, for the treatment of solid tumors. The drug demonstrated significant tumor growth inhibition in multiple preclinical models.', 'In November 2021, Nurix Therapeutics announced a collaboration with Gilead Sciences to develop novel ProTacs for the treatment of cancer and other diseases. The partnership will leverage Nurix's expertise in protein degradation and Gilead's experience in drug development.'

One of the major drivers behind the development of PROTACs is the need for increased target specificity in drug design. Conventional small-molecule drugs are often non-specific, and may target multiple proteins, leading to off-target effects and toxicity. PROTACs, on the other hand, are designed to specifically target a single protein or even a specific domain within a protein, reducing the risk of unintended effects. This increased target specificity not only enhances the safety profile of PROTACs but also allows for the development of therapies for diseases that were previously untreatable.

One key market trend in the PROTACs market is the increasing adoption of this technology in drug development. PROTACs offer a new approach to drug development by targeting disease-causing proteins for degradation rather than inhibition. This technology has the potential to provide better therapeutic outcomes, especially in diseases where current treatments have limited efficacy. As a result, there is a growing interest in PROTACs from pharmaceutical companies, academic and research institutions, and contract research organizations. Additionally, there is an increasing focus on research and development, which is expected to drive the growth of the market.

North America is one of the largest markets for PROTACs, with the United States being the dominant country in the region. The market is expected to grow significantly due to the increasing number of biotechnology and pharmaceutical companies in the region and the growing interest in targeted therapies for cancer and other diseases. The dominant players in the North American PROTACs market include Arvinas, C4 Therapeutics, Nurix, and Kymera Therapeutics. These companies are focused on developing PROTACs for a wide range of indications, including cancer, inflammatory diseases, and neurodegenerative diseases. Arvinas, in particular, has been successful in advancing its lead PROTAC candidate, ARV-110, for the treatment of prostate cancer, and has entered into a partnership with Pfizer for the development of additional PROTAC candidates. The North American PROTACs market is also characterized by a large number of academic and research institutions that are focused on developing new PROTACs and advancing the understanding of protein degradation as a therapeutic modality. For example, the University of Michigan has developed a novel class of PROTACs that target the androgen receptor for the treatment of prostate cancer, while the University of California, San Francisco is focused on developing PROTACs for the treatment of HIV.

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Global Proteolysis-targeting chimeric molecules (PROTACs) Market

Report ID: SQMIG35I2121

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